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mats for interm pathway scripting

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Alexander Pico 2020-03-19 16:03:42 -07:00
parent 215aae5400
commit 3983f0073a
4 changed files with 592 additions and 0 deletions
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126
intermediate-pathway-scripting/lung-wp-gsea.csv Normal file
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"","ID","Description","setSize","enrichmentScore","NES","pvalue","p.adjust","qvalues","rank","leading_edge","core_enrichment"
"WP2446","WP2446","Retinoblastoma Gene in Cancer",87,0.636565973412448,2.07894768186214,0.00165837479270315,0.0136986301369863,0.00729992790194665,4697,"tags=54%, list=19%, signal=44%","TOP2A/ANLN/POLE2/KIF4A/CCNB1/CCNA2/TTK/CHEK1/PLK4/MCM4/CCNB2/CDK1/RRM2/TYMS/CDC45/RFC4/CCNE2/ORC1/TFDP1/CCNE1/SKP2/CDT1/CDC25A/E2F2/CDC7/FANCG/MSH6/MCM6/BARD1/POLE/PRKDC/E2F3/SMC2/MCM7/RFC5/STMN1/DHFR/RFC3/RPA3/WEE1/HLTF/PRIM1/E2F1/HMGB2/PCNA/H2AFZ/MCM3"
"WP179","WP179","Cell Cycle",120,0.514478582141183,1.74942320154924,0.00166666666666667,0.0136986301369863,0.00729992790194665,4923,"tags=38%, list=20%, signal=31%","CDKN2A/CDC25C/CCNB1/CCNA2/TTK/CHEK1/CDC6/PLK1/ORC6/CDC20/MCM4/BUB1/CCNB2/CDK1/ESPL1/DBF4/CDC45/CCNE2/ORC1/PTTG1/TFDP1/MCM2/CCNE1/PKMYT1/SKP2/CDC25A/SMC1B/E2F2/CDC7/MCM6/PRKDC/E2F3/E2F5/CHEK2/MCM7/RBL1/CDKN2C/WEE1/GADD45A/E2F1/ORC2/PCNA/ATM/MCM3/ANAPC11/BUB3"
"WP4016","WP4016","DNA IR-damage and cellular response via ATR",80,0.608265656044446,1.96395220508954,0.00167785234899329,0.0136986301369863,0.00729992790194665,4611,"tags=44%, list=19%, signal=36%","CDC25C/BRIP1/CHEK1/PLK1/EXO1/FANCI/FOXM1/CDK1/CDC45/FANCD2/MSH2/FANCA/MCM2/BRCA1/RAD51/CLSPN/BRCA2/FEN1/TOPBP1/BARD1/POLB/PRKDC/EEF1E1/H2AFX/CHEK2/RMI1/CLK2/RBBP8/RFWD3/PALB2/E2F1/PCNA/SEM1/ATM/MRE11"
"WP2369","WP2369","Histone Modifications",67,0.622040510738319,1.9314019320563,0.00174825174825175,0.0136986301369863,0.00729992790194665,3552,"tags=40%, list=15%, signal=34%","EZH2/HIST1H4H/HIST1H4C/HIST1H3H/HIST1H4E/SUV39H2/HIST1H3B/HIST1H3J/HIST1H3D/HIST1H4D/HIST1H4I/HIST1H3C/HIST1H4B/HIST1H3F/EED/HIST1H4F/SMYD3/HIST1H4A/HIST1H3I/HIST1H4L/HIST1H3A/HIST4H4/HIST1H3G/HIST1H4J/HIST1H4K/KMT5C/SMYD5"
"WP466","WP466","DNA Replication",42,0.682437853191023,1.93537269381962,0.00177619893428064,0.0136986301369863,0.00729992790194665,4697,"tags=57%, list=19%, signal=46%","POLE2/CDC6/ORC6/MCM4/MCM10/DBF4/CDC45/RFC4/ORC1/MCM2/CDT1/GMNN/CDC7/MCM6/PRIM2/POLE/MCM7/RFC5/RFC3/RPA3/PRIM1/ORC2/PCNA/MCM3"
"WP2361","WP2361","Gastric Cancer Network 1",29,0.686964138085659,1.80275060612194,0.00178890876565295,0.0136986301369863,0.00729992790194665,3244,"tags=52%, list=13%, signal=45%","CENPF/TOP2A/TPX2/UBE2C/ECT2/E2F7/MCM4/MYBL2/KIF15/AURKA/KIF20B/S100P/RUVBL1/HIST4H4/ACTL6A"
"WP357","WP357","Fatty Acid Biosynthesis",22,-0.726399194516133,-1.84886866105561,0.00223713646532438,0.0136986301369863,0.00729992790194665,4344,"tags=64%, list=18%, signal=52%","ECH1/ACACA/ECHDC1/FASN/SCD/ACSL5/ACAA2/ACSL4/DECR1/PECR/ACSS2/ACACB/ACSL1"
"WP545","WP545","Complement Activation",22,-0.756514524093489,-1.92551974973147,0.00223713646532438,0.0136986301369863,0.00729992790194665,2934,"tags=59%, list=12%, signal=52%","C3/C1QC/C8B/C4A/C1QA/C4B/C7/C1QB/CFP/C5/CFD/MASP1"
"WP127","WP127","IL-5 Signaling Pathway",40,-0.642749664204508,-1.87301769330181,0.00227272727272727,0.0136986301369863,0.00729992790194665,3731,"tags=52%, list=15%, signal=45%","SYK/GSK3B/RAF1/MAP2K1/MAPK3/AKT1/IL2/RPS6KA1/FOS/GRB2/CSF2RB/STAT5B/JAK1/STAT3/STAT5A/MAPK1/PIK3R1/JUN/FOXO3/BTK"
"WP3937","WP3937","Microglia Pathogen Phagocytosis Pathway",40,-0.693804651206547,-2.02179551351968,0.00227272727272727,0.0136986301369863,0.00729992790194665,3031,"tags=55%, list=12%, signal=48%","FCGR1A/NCF4/PLCG2/C1QC/VAV1/RAC2/ITGB2/SIGLEC7/PIK3R3/FCER1G/TREM1/PTPN6/C1QA/CYBB/PIK3R1/C1QB/HCK/NCF1/ITGAM/NCKAP1L/NCF2"
"WP49","WP49","IL-2 Signaling Pathway",42,-0.654594269333697,-1.92105350035104,0.00227790432801822,0.0136986301369863,0.00729992790194665,3731,"tags=55%, list=15%, signal=46%","MAP2K1/MAPK3/CISH/FYN/SOCS3/CCND2/AKT1/IL2/CRKL/FOS/GRB2/STAT5B/JAK1/IL2RG/STAT3/STAT5A/PTK2B/MAPK1/PIK3R1/JUN/FOXO3/GAB2"
"WP1539","WP1539","Angiogenesis",24,-0.732880961801299,-1.89749435748104,0.00229357798165138,0.0136986301369863,0.00729992790194665,4385,"tags=62%, list=18%, signal=51%","FLT1/PDGFRA/TIMP2/MAPK14/AKT1/ARNT/KDR/MAPK1/FGFR2/TIMP3/TEK/FGF2/PDGFB/ANGPT1"
"WP98","WP98","Prostaglandin Synthesis and Regulation",45,-0.67707967450932,-2.02155511161406,0.00229885057471264,0.0136986301369863,0.00729992790194665,3864,"tags=60%, list=16%, signal=51%","PPARGC1B/EDNRA/ANXA2/ANXA4/PRL/TBXA2R/PTGIS/SCGB1A1/ABCC4/PTGER3/PTGFR/ANXA6/HSD11B1/PTGS1/HPGDS/HPGD/PTGER2/MITF/PTGIR/PTGER4/ANXA3/TBXAS1/PTGDS/PPARG/EDN1/EDNRB"
"WP4481","WP4481","Resistin as a regulator of inflammation",33,-0.728719111343713,-2.03471110257775,0.00230414746543779,0.0136986301369863,0.00729992790194665,5951,"tags=67%, list=25%, signal=50%","IKBKG/PLCD3/PLCB4/AKT3/TNF/CHUK/RELA/PLCG1/MAPK3/MAPK14/NFKB1/PLCG2/AKT1/ITPR1/IL6/PLCD1/MAPK1/RETN/PLCE1/NFKBIA/PLCB2"
"WP4149","WP4149","White fat cell differentiation",32,-0.717187214869053,-1.99503493862868,0.0023094688221709,0.0136986301369863,0.00729992790194665,4991,"tags=75%, list=21%, signal=60%","EBF1/RORA/CEBPB/INS/TLE3/TCF7L1/CTNNA1/EGR2/NR3C1/STAT5B/KLF4/RARA/NR2F2/GATA3/ZNF423/STAT5A/FOXO1/CEBPD/KLF2/CEBPA/KLF15/GATA2/PPARG"
"WP3942","WP3942","PPAR signaling pathway",67,-0.635560220456832,-2.05978992655891,0.00232558139534884,0.0136986301369863,0.00729992790194665,2954,"tags=37%, list=12%, signal=33%","CYP7A1/ACSL5/HMGCS2/ACAA1/PCK2/ACSL4/ILK/CPT1A/RXRA/SLC27A6/FABP1/APOA1/ACSL1/LPL/FABP3/SORBS1/ACADL/OLR1/PPARG/RXRG/FABP5/FABP4/CYP27A1/CD36"
"WP4155","WP4155","Endometrial cancer",63,-0.670921336651483,-2.1426216377604,0.00232558139534884,0.0136986301369863,0.00729992790194665,4412,"tags=46%, list=18%, signal=38%","DDB2/CCND1/PDPK1/RAF1/MAP2K1/MAPK3/TCF7L1/CTNNA3/CTNNB1/CTNNA1/APC/PTEN/SOS2/AKT1/CDKN1A/TCF7L2/FOS/GRB2/ARAF/ILK/PIK3R3/MAPK1/FGFR2/PIK3R1/FOXO3/FGF2/GADD45B/AXIN2"
"WP2637","WP2637","Structural Pathway of Interleukin 1 (IL-1)",49,-0.644842291521501,-1.94927613450899,0.00233100233100233,0.0136986301369863,0.00729992790194665,5196,"tags=55%, list=21%, signal=43%","MAP3K14/CHUK/RELA/MAPK10/TRAF6/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/MAP2K4/MAPK14/NFKB1/MAPK9/FOS/TOLLIP/MKNK1/MAP3K8/IL1R1/MKNK2/IL1A/MAPK1/MBP/NFKBIA/MYD88/MAP3K3"
"WP286","WP286","IL-3 Signaling Pathway",49,-0.763650610847904,-2.30841855504975,0.00233100233100233,0.0136986301369863,0.00729992790194665,3731,"tags=59%, list=15%, signal=50%","MAP2K1/MAPK3/FYN/YWHAB/CD86/AKT1/BCL2L1/CD69/INPP5D/CRKL/FOS/GRB2/CSF2RB/STAT5B/JAK1/VAV1/TGFB1/STAT3/STAT5A/PRKACA/PTPN6/RAPGEF1/MAPK1/PIK3R1/JUN/HCK/GAB2/IL3RA"
"WP4249","WP4249","Hedgehog Signaling Pathway",43,-0.655625827604928,-1.92858111322179,0.00234192037470726,0.0136986301369863,0.00729992790194665,4544,"tags=42%, list=19%, signal=34%","SHH/CCND1/PTCH1/DHH/GPR161/CDON/CCND2/SUFU/EVC/FBXL17/SPOP/PRKACA/GRK3/ARRB2/LRP2/HHIP/ARRB1"
"WP395","WP395","IL-4 Signaling Pathway",54,-0.658040267101942,-2.01956684134443,0.00235849056603774,0.0136986301369863,0.00729992790194665,3558,"tags=52%, list=15%, signal=44%","MAPK14/SOCS3/NFKB1/FES/IL4R/EP300/AKT1/STAT6/INPP5D/FOS/GRB2/FLNA/STAT5B/JAK1/IRS1/NFIL3/GATA3/IL2RG/STAT3/STAT5A/PTPN6/MAPK1/NFKBIA/PIK3R1/GAB2/CEBPA/DOK2"
"WP195","WP195","IL-1 signaling pathway",55,-0.64272055450148,-1.98054641301281,0.00237529691211401,0.0136986301369863,0.00729992790194665,5196,"tags=56%, list=21%, signal=44%","NFKBIB/MAP3K14/CHUK/RELA/SQSTM1/TRAF6/PLCG1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/MAP2K4/MAPK14/NFKB1/IL1B/AKT1/MAPK9/TOLLIP/IL1R1/IL1A/HSPB2/MAPK1/NFKBIA/IRAK3/PIK3R1/JUN/MYD88/MAP3K3/PRKCZ"
"WP2572","WP2572","Primary Focal Segmental Glomerulosclerosis FSGS",72,-0.564895810605214,-1.85209517787765,0.00237529691211401,0.0136986301369863,0.00729992790194665,4385,"tags=49%, list=18%, signal=40%","CTSL/LRP6/VIM/NPHS2/CR1/CD151/CTNNB1/CDKN1B/FYN/MYH9/COL4A5/AKT1/DAG1/NOTCH1/CDKN1A/COL4A3/ITGA3/SCARB2/ACTN4/TGFB1/ILK/UTRN/PARVA/VCL/LAMB2/TLN1/MME/CDKN1C/PLCE1/PTPRO/TLR4/TRPC6/SYNPO/COL4A4"
"WP2795","WP2795","Cardiac Hypertrophic Response",55,-0.562491502261919,-1.73332021101943,0.00237529691211401,0.0136986301369863,0.00729992790194665,5125,"tags=53%, list=21%, signal=42%","RAC1/MAP3K14/CHUK/GSK3B/MAP4K1/MAP2K3/PDPK1/RAF1/MAP2K1/TNFRSF1A/MAPK3/NFATC2/MAP2K4/MAPK14/HDAC5/NFKB1/MAPK7/AKT1/MAP2K5/HDAC7/CALM1/TGFB1/MEF2A/MAPK1/FGFR2/PRKG1/FGF2/PRKD1"
"WP560","WP560","TGF-beta Receptor Signaling",55,-0.618128504062653,-1.90476589386786,0.00237529691211401,0.0136986301369863,0.00729992790194665,3558,"tags=47%, list=15%, signal=40%","RUNX3/CTNNB1/THBS1/ITGB6/NFKB1/FKBP1A/ZEB2/EP300/MAPK9/FOS/TFE3/JAK1/TGFB1/BMP4/SKI/STAT3/ZNF423/ZFYVE9/JUN/LEFTY2/SMAD7/ENG/TGFBR2/TGFBR3/SMAD6"
"WP2203","WP2203","Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway",47,-0.678806935318986,-2.03356014944586,0.00238095238095238,0.0136986301369863,0.00729992790194665,3758,"tags=51%, list=15%, signal=43%","MAP2K1/MAPK3/CISH/MAPK14/FYN/NFKB1/FES/AKT1/MAPK9/STAT6/STAT5B/JAK1/STAT3/IL6/STAT5A/TSLP/PI4K2A/MAPK1/NFKBIA/HCK/GAB2/IL7R/BTK"
"WP2034","WP2034","Leptin signaling pathway",76,-0.60032634434338,-1.98738947622487,0.00239234449760766,0.0136986301369863,0.00729992790194665,5087,"tags=54%, list=21%, signal=43%","CHUK/JAK2/RELA/SP1/GSK3B/PLCG1/ACACA/CCND1/CFL2/RAF1/MAP2K1/MAPK3/CISH/MAPK14/PDE3B/FYN/SOCS3/NFKB1/IL1B/ROCK1/PTEN/ROCK2/PLCG2/AKT1/BCL2L1/RPS6KA1/GRB2/STAT5B/JAK1/IRS1/NCOA1/RHOA/STAT3/SOCS2/MAPK1/FOXO1/PIK3R1/PTPN1/ACACB/LEPR"
"WP2037","WP2037","Prolactin Signaling Pathway",76,-0.614835273428521,-2.03542150621455,0.00239234449760766,0.0136986301369863,0.00729992790194665,3758,"tags=42%, list=15%, signal=36%","RAF1/MAP2K1/MAPK3/CISH/MAPK14/FYN/SOCS3/NFKB1/PRL/AKT1/MAPK9/FOS/GRB2/FLNA/STAT5B/JAK1/VAV1/IRS1/CTSD/STAT3/STAT5A/SOCS2/PTPN6/MAPK1/NFKBIA/PIK3R1/JUN/PTPN1/GAB2/SIRPA/RPS6KA2"
"WP3945","WP3945","TYROBP Causal Network",61,-0.729451463583409,-2.29761362489514,0.00239234449760766,0.0136986301369863,0.00729992790194665,3574,"tags=57%, list=15%, signal=49%","TYROBP/ELF4/PYCARD/RUNX3/GIMAP2/IL13RA1/ABCC4/ZFP36L2/RNASE6/CAPG/SH2B3/C3/PLEK/LYL1/RPS6KA1/NRROS/C1QC/ITGB2/SLC7A7/HCLS1/HLX/GAPT/STAT5A/CXCL16/FKBP15/IL10RA/CD4/APBB1IP/ITGAM/NCKAP1L/BIN2/ITGAX/NCF2/CD37"
"WP304","WP304","Kit receptor signaling pathway",59,-0.701221359646638,-2.18048350455823,0.00244498777506112,0.0136986301369863,0.00729992790194665,3758,"tags=51%, list=15%, signal=43%","RAF1/MAP2K1/MAPK3/DOK1/MAPK14/JUNB/FYN/EP300/AKT1/RPS6KA1/MATK/INPP5D/CRKL/FOS/GRB2/STAT5B/CRK/VAV1/STAT3/STAT5A/PRKCB/PTPN6/MAPK1/PIK3R1/FOXO3/MITF/GAB2/BTK/TBX2"
"WP4341","WP4341","Non-genomic actions of 1,25 dihydroxyvitamin D3",71,-0.655504539161554,-2.13476766388158,0.00244498777506112,0.0136986301369863,0.00729992790194665,3689,"tags=46%, list=15%, signal=40%","MAPK3/ETS1/MAPK14/NFKB1/CD40/MAPK7/PLCG2/DEFB4A/MAPK9/CD40LG/JAK1/TLR2/IL6/CAMK2A/PRKCQ/RXRA/PRKCB/RSAD2/PLCD1/MAPK1/PLCE1/JUN/TLR8/PRKCZ/PRKCD/PLCB2/OAS2/TLR4/PRKCH/PRKCE/RXRG/CAV1"
"WP4298","WP4298","Viral Acute Myocarditis",84,-0.639586276038619,-2.14233412609757,0.00245700245700246,0.0136986301369863,0.00729992790194665,3558,"tags=50%, list=15%, signal=43%","MICA/EIF4G2/GSK3B/AIF1/CCND1/MAPK3/PYCARD/FYN/TLR5/AKT1/DAG1/SGCB/BCL2L1/CASP7/LAMA2/IL2/CD40LG/SGCD/JAK1/DMD/TLR3/RAC2/ITGB2/TGFB1/HLA-DMA/BNIP2/STAT3/IL6/CXCR4/CASP1/MAPK1/PIK3R1/CD4/NOS1/TLR4/ITGAL/PTCRA/SGCA/EDN1/SGCG/CAV1"
"WP23","WP23","B Cell Receptor Signaling Pathway",97,-0.612444610670313,-2.10875866219875,0.00246913580246914,0.0136986301369863,0.00729992790194665,3932,"tags=48%, list=16%, signal=41%","MAX/PDPK1/TEC/RAF1/MAP2K1/MEF2D/PTPRC/ETS1/NFATC2/PIK3AP1/MAPK14/PTPN18/FYN/NFKB1/PLCG2/GAB1/AKT1/PIP5K1C/MAPK9/BCL6/RPS6KA1/INPP5D/CRKL/GRB2/MAPK4/CRK/VAV1/RAC2/CD81/HCLS1/CAMK2A/PRKCB/NFATC3/PTPN6/RAPGEF1/MAPK1/FOXO1/NFKBIA/CD22/PIK3R1/JUN/KLF11/PRKCD/GAB2/BTK/PIP5K1B"
"WP2806","WP2806","Human Complement System",97,-0.642923121630133,-2.21370174256498,0.00246913580246914,0.0136986301369863,0.00729992790194665,3341,"tags=44%, list=14%, signal=38%","THBS1/FGG/FGA/CD40/C2/SELL/C3/FCN1/ITGB2/ICAM1/TLR2/C4A/DCN/C3AR1/PRKACA/FCGR3A/ITGA2B/ARRB2/CD93/C7/APOA1/GNAI2/CFP/F11/WAS/C5/ICAM2/SELP/SFTPA1/SERPING1/CFD/C5AR1/SFTPA2/CLEC4M/LRP2/C4BPA/FPR1/VSIG4/SELPLG/ITGAX/MASP1/PROS1"
"WP3931","WP3931","ESC Pluripotency Pathways",117,-0.483215380726575,-1.72146078193607,0.00246913580246914,0.0136986301369863,0.00729992790194665,3823,"tags=36%, list=16%, signal=30%","RAF1/MAP2K1/PDGFRA/WNT2/CTNNB1/FZD1/APC/MAPK7/PTEN/GAB1/WNT7A/AKT1/MAP2K5/LIFR/PDGFA/FOS/GRB2/FGF18/JAK1/MAPK4/ARAF/FGF7/FZD7/BMP4/FGF10/FZD5/STAT3/BMPR1A/IL6ST/MAPK1/FGFR2/JUN/FZD4/SMAD7/FGFR4/BMPR2/FGF2/WNT3A/PDGFB/SMAD6/SELENOP"
"WP2431","WP2431","Spinal Cord Injury",119,-0.467420960589209,-1.66836001096026,0.00247524752475248,0.0136986301369863,0.00729992790194665,3188,"tags=37%, list=13%, signal=32%","ROS1/IL1B/PDYN/FKBP1A/ROCK2/EGR1/FCGR2A/FCGR2C/PTPRA/CXCL2/IL2/BTG2/PLA2G5/FOS/MAG/GJA1/TGFB1/ICAM1/IL1R1/PLXNA2/RHOA/IL6/ZFP36/IL1A/MAPK1/RHOB/MBP/AQP1/C1QB/TNFSF13/C5/FOXO3/SELP/SEMA6A/NOS1/LILRB3/LOC102725035/BDNF/TLR4/AQP4/SLIT3/EFNB2/SLIT2"
"WP366","WP366","TGF-beta Signaling Pathway",132,-0.478303442833193,-1.73180872054833,0.00247524752475248,0.0136986301369863,0.00729992790194665,4442,"tags=45%, list=18%, signal=37%","SKP1/TRAF6/ZEB1/APP/RBL2/CCND1/MAP4K1/MAP2K3/TAB1/RAF1/MAP2K1/FOSB/YAP1/PRKAR2A/ETS1/LIMK2/MAP2K4/MAPK14/THBS1/JUNB/ATF3/FN1/PML/ROCK1/ZEB2/TGFB1I1/EP300/AKT1/DCP1A/KLF10/MAPK9/CDKN1A/FOS/JUND/GRB2/MAPK4/WWP1/TGFB1/SKI/RHOA/MEF2A/MAPK1/ZFYVE9/NEDD4L/SIK1/DAB2/PIAS1/PIK3R1/JUN/SPTBN1/KLF11/NEDD9/SMAD7/KLF6/CDKN2B/TGFBR2/TGFBR3/CAV1"
"WP3915","WP3915","Angiopoietin Like Protein 8 Regulatory Pathway",132,-0.52741840164463,-1.9096408379071,0.00247524752475248,0.0136986301369863,0.00729992790194665,4412,"tags=39%, list=18%, signal=32%","MAPKAP1/CAP1/MAP3K4/MLXIPL/INS/MAP4K1/MAP2K3/FASN/PDPK1/SCD/RAF1/MAP2K1/MAPK3/FLOT2/MAP2K4/MAPK14/SREBF2/RHOQ/PRKAB1/MAPK7/MAP3K11/CYP7A1/MINK1/TRIP10/SOS2/AKT1/MAP2K5/MAPK9/RPS6KA1/SHC3/MAPK4/CRK/IRS1/MAP4K2/MAP3K8/PIK3R3/PIK3C2G/RXRA/MAP3K6/RAPGEF1/THRB/MAPK1/FOXO1/THRA/PIK3R1/PTPN1/MAP3K3/FOXO3/LPL/RPS6KA2/FBP1"
"WP1544","WP1544","MicroRNAs in cardiomyocyte hypertrophy",98,-0.544054587205048,-1.87677876598414,0.00248138957816377,0.0136986301369863,0.00729992790194665,3906,"tags=39%, list=16%, signal=33%","MAP2K3/TAB1/PDPK1/RAF1/MAP2K1/MAPK3/CISH/CTNNB1/FZD1/MAP2K4/MAPK14/HDAC5/NFKB1/ROCK1/MAPK7/ROCK2/AKT1/MAP2K5/RCAN1/HDAC7/CALM1/MAPK4/TGFB1/PIK3R3/RHOA/STAT3/IL6ST/PRKCB/MAPK1/FGFR2/PIK3R1/PRKG1/MYLK/PLCB2/FGF2/WNT3A/EDN1"
"WP236","WP236","Adipogenesis",130,-0.474985938357607,-1.7171574020515,0.00248138957816377,0.0136986301369863,0.00729992790194665,3747,"tags=35%, list=15%, signal=30%","MEF2D/CNTFR/CTNNB1/FZD1/SOCS3/EGR2/PTGIS/LIFR/KLF7/STAT6/ID3/CDKN1A/PCK2/NR3C1/STAT5B/IRS1/TGFB1/WWTR1/RARA/BMP4/NCOA1/GATA3/STAT3/IL6/STAT5A/RXRA/BMP2/IL6ST/MEF2A/RETN/FOXO1/CEBPD/FRZB/CFD/PLIN2/LPL/CEBPA/KLF15/KLF6/GDF10/GATA2/GADD45B/PPARG/RXRG/EPAS1"
"WP4540","WP4540","Pathways Regulating Hippo Signaling",98,-0.521323028062473,-1.79836364272296,0.00248138957816377,0.0136986301369863,0.00729992790194665,3799,"tags=35%, list=16%, signal=29%","GNA11/PDGFRA/PRKAR2A/TCF7L1/CTNNB1/CSF1R/PRKAB1/CDH9/FLT4/TCF7L2/PRKAR1A/CDH6/CDH10/RHOA/PRKCQ/PRKACA/CDH19/PRKCB/KDR/NTRK2/FGFR2/GNAI2/PRKCZ/LATS2/PRKCD/CDH13/FGFR4/PLCB2/TEK/PRKCH/PRKCE/GNAQ/CDH5"
"WP536","WP536","Calcium Regulation in the Cardiac Cell",149,-0.516859634478407,-1.89197755115013,0.00248138957816377,0.0136986301369863,0.00729992790194665,3912,"tags=43%, list=16%, signal=36%","GNG5/RGS19/PRKAR2B/ADRB3/GNA11/PRKAR2A/YWHAH/ADCY5/ATP2B3/RGS16/CAMK1/YWHAB/FKBP1A/RGS18/CACNA1C/RYR1/GNG2/PKIA/CACNA1D/SLC8A1/RGS2/PLN/GJA4/PRKAR1A/CALM1/GJA1/ANXA6/GNAI1/ITPR1/CAMK2A/PRKCQ/PRKACA/RGS6/CASQ2/PRKCB/PKIG/ARRB2/CHRM1/ADCY4/GJC2/ADCY9/GNAI2/ATP1B2/PRKCZ/GNG7/ADRA1A/SLC8A3/PRKCD/GJA5/RGS5/PRKCH/CACNA1S/ARRB1/PRKCE/PRKD1/ADRA1B/GNAQ/CHRM2/RGS9/ADRB1/ADRB2/KCNJ5/GRK5"
"WP138","WP138","Androgen receptor signaling pathway",90,-0.525276462659242,-1.77249607836137,0.00249376558603491,0.0136986301369863,0.00729992790194665,5087,"tags=47%, list=21%, signal=37%","RAC1/RELA/TLE5/KAT7/SMAD4/SIN3A/SP1/SIRT1/GSK3B/NCOR2/RNF6/CCND1/KAT5/LIMK2/CTNNB1/ROCK1/PTEN/ROCK2/TGFB1I1/DSTN/EP300/AKT1/RNF14/CDKN1A/FLNA/NCOA1/RHOA/STAT3/KLK3/ZMIZ1/FOXO1/RHOB/PIAS1/PIK3R1/JUN/NCOA4/AR/KAT2B/ETV5/PLPP1/CAV1"
"WP51","WP51","Regulation of Actin Cytoskeleton",151,-0.543185017975121,-1.9920987618635,0.00249376558603491,0.0136986301369863,0.00729992790194665,3827,"tags=39%, list=16%, signal=33%","CFL2/RAF1/MAP2K1/PDGFRA/MAPK3/ARHGAP35/PIP4K2B/SSH1/ITGA1/TMSB4X/APC/FN1/PAK4/ROCK1/ROCK2/CYFIP2/PAK5/SOS2/PIP5K1C/PDGFA/RRAS2/SSH2/FGF18/IQGAP1/MAPK4/CRK/VAV1/RAC2/FGF7/DIAPH1/EZR/PIK3R3/FGF10/RHOA/GSN/PIK3C2G/WASF2/VCL/RDX/CHRM1/MAPK1/RRAS/FGFR2/MYL3/PIK3R1/PIK3R5/SLC9A1/WAS/MYLK/MSN/MRAS/FGFR4/ARHGEF6/MYH10/FGF2/PDGFB/CHRM2/PIP5K1B"
"WP69","WP69","T-Cell antigen Receptor (TCR) Signaling Pathway",90,-0.602333142752611,-2.03251660657157,0.00249376558603491,0.0136986301369863,0.00729992790194665,5173,"tags=57%, list=21%, signal=45%","GRAP2/SKAP1/MAP3K14/CHUK/RELA/CD8A/TRAF6/PLCG1/ICOS/VIM/MAP4K1/CD3E/PDPK1/RAF1/MAP2K1/MAPK3/LCP2/NFATC2/MAPK14/DBNL/FYN/NFKB1/IL1B/AKT1/SH2B3/MAPK9/CRKL/FOS/GRB2/NFATC1/CD247/CRK/VAV1/TGFB1/MAP3K8/ITPR1/GATA3/IL6/PRKCQ/IL1A/PTK2B/MAPK1/NFKBIA/CD83/PIK3R1/JUN/WAS/PRKCD/CD4/GAB2"
"WP4541","WP4541","Hippo-Merlin Signaling Dysregulation",121,-0.476114960490584,-1.70282708999761,0.0025,0.0136986301369863,0.00729992790194665,3848,"tags=34%, list=16%, signal=29%","PRKAR2B/PDGFRA/PRKAR2A/CTNNB1/ITGA1/CTNNA1/ITGB6/CSF1R/PAK4/CDH9/PAK5/AJUBA/FLT4/PRKAR1A/CDH6/ITGA3/ITGB2/ITGA9/CDH10/PRKACA/ITGAE/CDH19/CCN2/SAV1/KDR/ITGA10/ITGA2B/NTRK2/CD44/FGFR2/LATS2/CDH13/FGFR4/ITGAM/TEK/PPP1R14A/ITGAL/ITGAX/ITGA8/CDH5"
"WP231","WP231","TNF alpha Signaling Pathway",92,-0.508347384485388,-1.72409999242593,0.00251256281407035,0.0136986301369863,0.00729992790194665,5196,"tags=41%, list=21%, signal=33%","TNF/RAC1/MAP3K14/CHUK/PYGL/PPP2CA/SKP1/RIPK3/RIPK1/MAP2K3/TAB1/RAF1/TNFRSF1A/TNFRSF1B/TAB2/MAPK3/NSMAF/MAP2K4/NFKB1/FBXW11/AKT1/OTUD7B/BCL2L1/CASP7/MAPK9/CFLAR/GRB2/MAP4K2/TNFAIP3/MAP3K8/IL6/GLUL/MAPK1/NFKBIA/JUN/MAP3K3/PRKCZ"
"WP185","WP185","Integrin-mediated Cell Adhesion",102,-0.583190075319158,-2.02092896305995,0.00252525252525253,0.0136986301369863,0.00729992790194665,3848,"tags=52%, list=16%, signal=44%","ITGAD/MAPK10/DOCK1/CAPN9/PXN/CAPN3/VASP/ITGB7/MAP2K3/PDPK1/RAF1/MAP2K1/ITGA1/FYN/ITGB6/CAPN2/PAK4/ROCK1/MAPK7/ROCK2/CAPNS1/AKT1/MAP2K5/SHC3/GRB2/MAPK4/ARAF/CRK/RAP1A/ITGA3/RAC2/ITGB2/ILK/ITGA9/ZYX/ITGAE/VCL/RAPGEF1/ITGA10/ITGA2B/MAPK1/TLN1/CAV3/ITGAM/CAV2/SORBS1/ITGAL/ITGAX/TNS1/ITGA8/SELENOP/CAV1"
"WP399","WP399","Wnt Signaling Pathway and Pluripotency",102,-0.50786031199826,-1.75988868319521,0.00252525252525253,0.0136986301369863,0.00729992790194665,3454,"tags=37%, list=14%, signal=32%","TCF7L1/CTNNB1/FZD1/MAP2K4/CTNND1/APC/CCND2/EP300/WNT7A/MMP7/FBXW2/MAPK9/PPP2R5C/TCF7L2/LRRK2/FRAT1/PAFAH1B1/PPP2CB/FZD7/RHOA/FZD5/PRKCQ/PRKCB/CD44/JUN/PRKCZ/PRKCD/FZD4/LDLR/NKD2/CCND3/PRKCH/WNT3A/PRKCE/PRKD1/NKD1/AXIN2"
"WP1449","WP1449","Regulation of toll-like receptor signaling pathway",143,-0.507378430442551,-1.85054502255692,0.00253164556962025,0.0136986301369863,0.00729992790194665,5125,"tags=41%, list=21%, signal=33%","RAC1/CCL5/CHUK/RELA/TIRAP/SQSTM1/SYK/MAPK10/TRAF6/CCL4/OTUD5/IFNA14/RIPK1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/CISH/TRAFD1/RNF41/TLR7/MAP2K4/MAPK14/NFKB1/IL1B/TLR5/CD40/CD86/AKT1/SFTPD/MAPK9/CTNNAL1/FOS/TLR3/TNFAIP3/TOLLIP/MAP3K8/TLR2/PIK3R3/PELI3/IRF5/IL6/TREM1/PTPN6/ZMYND11/MAPK1/NFKBIA/IRAK3/PIK3R1/PIK3R5/JUN/MYD88/TLR8/SFTPA2/BTK/TLR4/SMAD6"
"WP35","WP35","G Protein Signaling Pathways",94,-0.589402590436537,-2.00316087263184,0.00253164556962025,0.0136986301369863,0.00729992790194665,2550,"tags=40%, list=11%, signal=36%","PRKAR2B/GNA11/AKAP11/PRKAR2A/ADCY5/PDE4B/PDE8A/PRKAR1A/AKAP4/PDE4A/AKAP7/CALM1/PDE8B/GNAI1/ITPR1/RHOA/PPP3CC/PDE1C/PRKCQ/PRKACA/PRKCB/AKAP2/AKAP13/GNGT2/RRAS/ADCY4/ADCY9/GNAI2/PRKCZ/GNG7/SLC9A1/PRKCD/PDE1B/PRKCH/PRKCE/PRKD1/GNAQ"
"WP4217","WP4217","Ebola Virus Pathway on Host",129,-0.604719341351543,-2.17244775160068,0.00253164556962025,0.0136986301369863,0.00729992790194665,4950,"tags=51%, list=20%, signal=41%","ITGA5/ACTB/NPC2/TIMD4/TPCN2/HLA-F/BST2/CLTB/ADAM17/CTSL/HLA-DQB1/EPS15/DDX58/ICAM3/RFC1/HLA-DOB/MAPK3/ITGA1/SOCS3/NFKB1/RAB7A/VPS18/FOLR1/TYRO3/HLA-DMB/CLEC6A/EP300/AKT1/VPS11/AXL/RAB5A/HLA-DRB5/CLEC10A/HLA-DRB1/FLNA/HAVCR2/IQGAP1/ITGA3/ACTN4/RAB9A/HLA-DRA/PIK3R3/HLA-DMA/VPS39/RHOA/GSN/HLA-DQA2/HLA-DQA1/ASGR1/HLA-DQB2/HLA-G/MAPK1/HLA-DPB1/RHOB/HLA-E/PIK3R1/DAB2IP/ICAM2/CAV3/CLEC4M/CAV2/TLR4/HLA-DPA1/HLA-DOA/CAV1"
"WP4666","WP4666","Hepatitis B infection",152,-0.478187392186986,-1.75338279172837,0.00253164556962025,0.0136986301369863,0.00729992790194665,5024,"tags=38%, list=21%, signal=30%","CHUK/JAK2/RELA/TIRAP/SMAD4/MAPK10/TRAF6/DDB2/MAVS/IFNA14/DDX58/MAP2K3/TAB1/RAF1/MAP2K1/TAB2/MAPK3/NFATC2/IFIH1/MAP2K4/DDX3X/MAPK14/TGFB2/YWHAB/NFKB1/EGR2/CASP10/SOS2/EP300/AKT1/MAPK9/STAT6/CDKN1A/FOS/GRB2/NFATC1/STAT5B/JAK1/ATP6AP1/ARAF/TLR3/TGFB1/TLR2/PIK3R3/STAT3/IL6/STAT5A/PRKCB/NFATC3/PTK2B/MAPK1/PIK3R1/JUN/MYD88/CASP12/TLR4/TGFBR2"
"WP2380","WP2380","Brain-Derived Neurotrophic Factor (BDNF) signaling pathway",144,-0.521528155745828,-1.89448800527984,0.00255754475703325,0.0136986301369863,0.00729992790194665,3762,"tags=38%, list=15%, signal=32%","RAF1/MAP2K1/MAPK3/CTNNB1/ALPL/MAPK14/CYFIP1/CAMK1/FYN/NFKB1/EGR2/APC/KCNN2/MAPK7/RHOG/EGR1/AKT1/MAP2K5/MAPK9/RPS6KA1/FOS/SHC3/GRB2/STAT5B/RAP1A/IRS1/KCNA3/KIDINS220/CDKL5/STAT3/CAMK2A/STAT5A/BMP2/PTK2B/MEF2A/NTRK3/MAPK1/NTRK2/NFKBIA/PIK3R1/JUN/ACACB/FOXO3/PRKCD/SIRPA/NCF1/BDNF/CNR1/NCF2/RASGRF1/SORT1/GRIA1/DPYSL2"
"WP2355","WP2355","Corticotropin-releasing hormone signaling pathway",93,-0.531240232360081,-1.79886540543531,0.00256410256410256,0.0136986301369863,0.00729992790194665,4685,"tags=48%, list=19%, signal=39%","GRK6/GSK3B/PLCG1/ACACA/CRHBP/FOSL2/POMC/RAF1/MAP2K1/GNA11/FOSB/MAPK3/TCF4/CTNNB1/MAPK14/JUNB/NFKB1/PLCG2/CRH/AKT1/ERN1/MAPK9/IL2/FOS/JUND/KRT1/GJA1/TGFB1/GNAI1/RHOA/CAMK2A/PRKCQ/RAPGEF3/PRKCB/GRK3/ARRB2/MAPK1/NFKBIA/GNAI2/PRKCD/CASP12/TLR4/ARRB1/GNAQ"
"WP306","WP306","Focal Adhesion",198,-0.518087693346908,-1.9576602945688,0.00261780104712042,0.0136986301369863,0.00729992790194665,3848,"tags=37%, list=16%, signal=31%","PDPK1/RAF1/MAP2K1/PDGFRA/LAMC3/MAPK3/ARHGAP35/CTNNB1/ITGA1/THBS1/FYN/ITGB6/FN1/CAPN2/PAK4/CCND2/MYL12A/ROCK1/PTEN/ROCK2/AKT1/PIP5K1C/PDGFA/PPP1R12C/MAPK9/LAMA2/CRKL/SHC3/GRB2/FLNA/PARVB/CRK/RAP1A/VAV1/ITGA3/RAC2/ACTN4/ILK/ITGA9/DIAPH1/PIK3R3/RHOA/PARVA/ZYX/PRKCB/VCL/LAMB2/KDR/RAPGEF1/ITGA10/ITGA2B/MAPK1/TLN1/PIK3R1/JUN/TNXB/MYL9/HCK/LAMA3/MYLK/CAV3/CAV2/PARVG/CCND3/VWF/PDGFB/COL4A4/VEGFD/RASGRF1/FGR/ITGA8/CAV1"
"WP481","WP481","Insulin Signaling",160,-0.558049183557073,-2.05099522607501,0.00261780104712042,0.0136986301369863,0.00729992790194665,3932,"tags=38%, list=16%, signal=32%","PPP1R3A/MAP2K3/PDPK1/RAF1/MAP2K1/MAPK3/FLOT2/STXBP1/MAP2K4/MAPK14/SOCS3/TBC1D4/RHOQ/MAPK7/MAP3K11/PTEN/MINK1/EGR1/SOS2/GAB1/AKT1/MAP2K5/MAPK9/RPS6KA1/SNAP23/FOS/SHC3/GRB2/SGK3/MAPK4/CRK/RAC2/IRS1/MAP4K2/STXBP2/MAP3K8/PIK3R3/PIK3C2G/PRKCQ/MAP3K6/PRKCB/RAPGEF1/MAPK1/FOXO1/EHD1/PIK3R1/JUN/PTPN1/MYO1C/VAMP2/MAP3K3/PRKCZ/FOXO3/SGK1/PRKCD/SORBS1/PRKCH/RPS6KA2/EHD2/RHOJ"
"WP706","WP706","Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways",160,-0.402371045121336,-1.47883218356196,0.00261780104712042,0.0136986301369863,0.00729992790194665,3799,"tags=32%, list=16%, signal=28%","PPARGC1B/TAC1/PRKAR2A/YWHAH/RUNX3/CTNNB1/SLC1A3/YWHAB/NFKB1/IL1B/MECP2/EGR1/CHRNA4/EP300/SSTR1/HADHB/PRKAR1A/NR3C1/KCNQ1/SLC25A4/GJA1/HADHA/C4A/TPPP/GATA3/CPT1A/IL6/PRKACA/PBX1/IL1A/C4B/THRB/NTRK2/JUN/SPTBN1/AR/TSPYL1/VAMP2/GPD1L/KCNJ8/FMO3/CAV3/BDNF/IL6R/SCN4B/AQP4/GATA2/VIPR1/CHRM2/MAOA/SLC6A4"
"WP289","WP289","Myometrial Relaxation and Contraction Pathways",156,-0.495512547324554,-1.8138804577885,0.00263157894736842,0.0136986301369863,0.00729992790194665,3857,"tags=39%, list=16%, signal=33%","RGS19/CNN2/PRKAR2B/ACTA2/PRKAR2A/YWHAH/ADCY5/MYL4/RGS16/GUCY1A1/YWHAB/NFKB1/IL1B/ATF3/RGS18/PLCG2/RYR1/GNG2/CRH/CNN1/PKIA/ETS2/PDE4B/SLC8A1/RGS2/FOS/PRKAR1A/MAFF/IGFBP1/CALM1/GJA1/ITPR1/IL6/CAMK2A/PRKCQ/PRKACA/RGS6/PRKCB/PKIG/PLCD1/ARRB2/ADCY4/JUN/ADCY9/PRKCZ/GNG7/PRKCD/NOS1/RGS5/PRKCH/ARRB1/PRKCE/GUCA2A/PRKD1/GNAQ/RXFP1/RGS9/RAMP2/RAMP3/GRK5"
"WP3929","WP3929","Chemokine signaling pathway",164,-0.529961471137152,-1.95216415864642,0.00263852242744063,0.0136986301369863,0.00729992790194665,2991,"tags=32%, list=12%, signal=29%","ROCK1/ROCK2/GNG2/SOS2/AKT1/CXCL12/CRKL/SHC3/GRB2/CCL24/STAT5B/CRK/RAP1A/VAV1/RAC2/PF4/GNAI1/PIK3R3/CCR1/STAT3/CXCR4/CXCL16/PRKCB/GNGT2/PTK2B/DOCK2/ARRB2/MAPK1/XCR1/ADCY4/NFKBIA/PIK3R1/PIK3R5/ADCY9/GNAI2/CXCR2/HCK/PRKCZ/GNG7/WAS/FOXO3/PRKCD/NCF1/CX3CL1/RASGRP2/ELMO1/PLCB2/ARRB1/CX3CR1/PREX1/FGR/GRK5"
"WP437","WP437","EGF/EGFR Signaling Pathway",163,-0.567435392513956,-2.08919690999873,0.00263852242744063,0.0136986301369863,0.00729992790194665,4418,"tags=42%, list=18%, signal=35%","PIK3C2B/PLCG1/AP2M1/MAP3K4/EPS15/MAP4K1/PDPK1/RAF1/MAP2K1/FOSB/MEF2D/LIMK2/STXBP1/PTPN12/MAPK14/STAM/RALBP1/ROCK1/MAPK7/PTEN/USP8/SOS2/GAB1/AKT1/MAP2K5/RAB5A/MAPK9/RPS6KA1/INPP5D/CRKL/FOS/JUND/GRB2/STAT5B/JAK1/IQGAP1/MAPK4/CRK/RAP1A/VAV1/GJA1/IQSEC1/PTPN5/STAT3/CAMK2A/STAT5A/SH3KBP1/PRKCB/PEBP1/PTK2B/MEF2A/MAPK1/FOXO1/SH3GL3/FOXO4/PLCE1/PIK3R1/JUN/MAP3K3/PRKCZ/PRKCD/SPRY2/GAB2/CAV2/DOK2/RPS6KA2/REPS2/CAV1"
"WP4223","WP4223","Ras Signaling",184,-0.475218887563424,-1.77943506956402,0.00268096514745308,0.0136986301369863,0.00729992790194665,3925,"tags=35%, list=16%, signal=30%","GNG5/RAF1/MAP2K1/PDGFRA/STK4/MAPK3/PLA2G4E/PLA2G4D/ETS1/PLA2G3/SHOC2/NFKB1/RALBP1/CSF1R/PAK4/PLA1A/PLCG2/GNG2/PAK5/SOS2/RGL1/GAB1/AKT1/ETS2/RAB5A/RRAS2/BCL2L1/MAPK9/FLT4/PLA2G5/SHC3/GRB2/PLAAT3/CALM1/RAP1A/RAC2/PIK3R3/RHOA/PRKACA/PRKCB/KDR/GNGT2/PLA2G4C/RAPGEF5/RAB5B/MAPK1/RRAS/NTRK2/FGFR2/FOXO4/PLCE1/PIK3R1/GNG7/GAB2/MRAS/FGFR4/RASGRP2/RASSF5/PLA2G12B/RASGRP4/TEK/PLA2G4F/PLA2G1B/RASGRF1"
"WP3888","WP3888","VEGFA-VEGFR2 Signaling Pathway",236,-0.589062517396146,-2.26327859348876,0.00271739130434783,0.0136986301369863,0.00729992790194665,3823,"tags=40%, list=16%, signal=34%","CAMKK2/PDPK1/RAF1/MAP2K1/F3/ELOA/MAPK3/DOK1/ETS1/NFATC2/CTNNB1/MAP2K4/CTNNA1/MAPK14/HDAC5/STAM/OCLN/FGG/FYN/MYH9/NFKB1/FGA/CTNND1/CAPN2/ROCK1/PTPRJ/ROCK2/EGR1/SHB/FBXW11/GAB1/AKT1/RAB11A/ERN1/HBEGF/RCAN1/SLC8A1/RAB5A/HDAC7/BCL2L1/MAPK9/STAT6/PLA2G5/SOD2/GRB2/NFATC1/IQGAP1/CRK/RAP1A/GJA1/ICAM1/MKNK1/EZR/RHOA/PTPN9/ADAMTS1/STAT3/PRKCB/CCN2/VCL/PTPN6/KDR/RAPGEF1/PTK2B/ARRB2/MAPK1/FOXO1/FOXO4/NFKBIA/PIK3R1/JUN/PTPN1/PRKG1/TNXB/SMARCA2/ACACB/PRKCZ/FOXO3/PRKCD/ERG/NCF1/ARHGEF15/NOTCH4/MMRN2/PRKCE/PRKD1/RCAN2/RHOJ/TXNIP/NCF2/CDH5/KL/CAV1"
"WP382","WP382","MAPK Signaling Pathway",246,-0.489721566933744,-1.8914958861666,0.00273972602739726,0.0136986301369863,0.00729992790194665,3932,"tags=36%, list=16%, signal=31%","MAX/MAPKAPK3/PPP5D1/MAP2K3/TAB1/CACNG2/RAF1/MAP2K1/TNFRSF1A/STK4/TAB2/MAPK3/PLA2G4E/PLA2G4D/MAP2K4/PPM1B/MAPK14/TGFB2/CACNG4/NFKB1/IL1B/TAOK3/MAPK7/MAP3K11/CACNA1C/TAOK2/SOS2/AKT1/MAP2K5/CACNA1D/PDGFA/CACNB4/RRAS2/RAPGEF2/MAPK9/CACNA2D2/CRKL/FOS/LRRK2/JUND/GRB2/FLNA/NFATC1/FGF18/ARAF/CRK/RAP1A/RAC2/DUSP7/MAP4K2/FGF7/TGFB1/MKNK1/MAP3K8/DUSP16/IL1R1/FGF10/PTPN5/PPP3CC/PRKACA/MAP3K6/MKNK2/NFATC3/IL1A/PLA2G4C/DUSP3/ARRB2/MAPK1/RRAS/NTRK2/FGFR2/JUN/HSPA2/PRKCD/DUSP6/MRAS/FGFR4/BDNF/RASGRP2/DUSP1/RASGRP4/PLA2G4F/FGF2/CACNA1S/PDGFB/ARRB1/TGFBR2/RASGRF1"
"WP3959","WP3959","DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM",55,0.582197440322824,1.76019258020718,0.00344234079173838,0.0169469085131736,0.00903091835241487,6494,"tags=45%, list=27%, signal=33%","CDKN2A/CDC25C/CHEK1/EXO1/FANCD2/BRCA1/RAD51/BLM/BRCA2/CASP3/PRKDC/H2AFX/CHEK2/ACTL6A/E2F1/PCNA/ATM/MRE11/RIF1/PARP1/ATR/RAD9A/TP73/RAD52/CDK5"
"WP45","WP45","G1 to S cell cycle control",64,0.556928674132859,1.71459626479989,0.00350877192982456,0.0170122275385433,0.00906572651725006,4697,"tags=48%, list=19%, signal=39%","CDKN2A/POLE2/CCNB1/ORC6/MCM4/CDK1/CDC45/CCNE2/ORC1/TFDP1/MCM2/CCNE1/CDC25A/E2F2/MCM6/MYT1/PRIM2/CREB3L4/POLE/E2F3/MCM7/CDKN2C/RPA3/WEE1/PRIM1/GADD45A/E2F1/ORC2/PCNA/ATM/MCM3"
"WP3965","WP3965","Lipid Metabolism Pathway",29,-0.644170593288779,-1.7565770866349,0.00451467268623025,0.0184997832056656,0.00985843710301915,4413,"tags=48%, list=18%, signal=40%","PRKACB/BCKDHA/ACACA/PRKAR2B/FASN/PRKAR2A/PNPLA2/PRKAB1/AKT1/PRKAR1A/PRKACA/ACSS2/ABHD5"
"WP3972","WP3972","PDGFR-beta pathway",29,-0.703598072588881,-1.91862880017568,0.00451467268623025,0.0184997832056656,0.00985843710301915,5099,"tags=59%, list=21%, signal=46%","JAK2/PLCG1/RAF1/MAP2K1/MAPK3/MAP2K4/STAT6/FOS/GRB2/STAT5B/JAK1/STAT3/STAT5A/PRKCB/PIK3R1/JUN"
"WP2526","WP2526","PDGF Pathway",40,-0.612454490672276,-1.78473542851409,0.00454545454545455,0.0184997832056656,0.00985843710301915,5099,"tags=52%, list=21%, signal=42%","RAC1/CHUK/PLCG1/RAF1/MAP2K1/MAPK3/MAP2K4/NFKB1/PDGFA/FOS/GRB2/JAK1/VAV1/RHOA/STAT3/MAPK1/NFKBIA/PIK3R1/JUN/PDGFB"
"WP3298","WP3298","Melatonin metabolism and effects",38,-0.627506056973278,-1.81250107551413,0.00455580865603645,0.0184997832056656,0.00985843710301915,4443,"tags=53%, list=18%, signal=43%","TRAF6/GSK3B/MAP2/CYP1B1/CYP1A1/NFKB1/PER3/CRY1/APOE/CALM1/SULT1A1/CAMK2A/PER1/FOXO1/CRY2/CYP1A2/MAOA/EDN1/ADRB1"
"WP143","WP143","Fatty Acid Beta Oxidation",34,-0.643312671618906,-1.80765765982521,0.0045662100456621,0.0184997832056656,0.00985843710301915,3837,"tags=44%, list=16%, signal=37%","ACADS/ACAT1/PNPLA2/ACSL5/HADHB/ACSL4/HADHA/CPT1A/SLC25A20/DECR1/ACSS2/ACSL1/LPL/ACADL"
"WP2197","WP2197","Endothelin Pathways",34,-0.610275753893501,-1.71482653738974,0.0045662100456621,0.0184997832056656,0.00985843710301915,3731,"tags=47%, list=15%, signal=40%","MAP2K1/EDNRA/CNN1/NPY1R/CALM1/GNAI1/NPY/MAPK1/ADRA1A/MYLK/PTGIR/CALCRL/EDN1/ADRB1/EDNRB"
"WP313","WP313","Signaling of Hepatocyte Growth Factor Receptor",34,-0.634577940990779,-1.78311375851093,0.0045662100456621,0.0184997832056656,0.00985843710301915,4542,"tags=56%, list=19%, signal=45%","PXN/MAP4K1/RAF1/MAP2K1/MAPK3/ITGA1/PTEN/GAB1/CRKL/FOS/GRB2/CRK/RAP1A/STAT3/RAPGEF1/PTK2B/MAPK1/JUN"
"WP422","WP422","MAPK Cascade",33,-0.670850003116976,-1.87313043977875,0.00460829493087558,0.0184997832056656,0.00985843710301915,4622,"tags=48%, list=19%, signal=39%","MAP2/MAP2K3/RAF1/MAP2K1/MAPK3/MAP2K4/MAPK14/SOS2/GRB2/ARAF/MAPK1/RRAS/MBP/JUN/MAP3K3"
"WP2324","WP2324","AGE/RAGE pathway",66,-0.612892706020922,-1.97297630344254,0.00464037122969838,0.0184997832056656,0.00985843710301915,3731,"tags=56%, list=15%, signal=48%","CHUK/JAK2/RELA/TIRAP/SP1/INS/RAF1/MAP2K1/MAPK3/ALPL/MAPK14/NFKB1/ROCK1/AKT1/MMP7/MAPK9/STAT5B/IRS1/DIAPH1/EZR/RHOA/STAT3/STAT5A/PRKCB/MAPK1/FOXO1/FOXO4/NFKBIA/JUN/MYD88/PRKCZ/PRKCD/MSN/NCF1/MSR1/AGER"
"WP2374","WP2374","Oncostatin M Signaling Pathway",65,-0.597863939945069,-1.91873157520145,0.00465116279069767,0.0184997832056656,0.00985843710301915,3731,"tags=49%, list=15%, signal=42%","MAP2K1/MAPK3/MAPK14/CDKN1B/JUNB/SOCS3/NFKB1/EGR1/AKT1/LIFR/CASP7/MAPK9/FOS/JUND/GRB2/STAT5B/JAK1/IRS1/CCN1/STAT3/IL6ST/PRKCB/PTK2B/MAPK1/NFKBIA/PIK3R1/TIMP3/PRKCD/LDLR/PRKCH/PRKCE"
"WP2849","WP2849","Hematopoietic Stem Cell Differentiation",63,-0.597628338095296,-1.90855669448911,0.00465116279069767,0.0184997832056656,0.00985843710301915,3661,"tags=48%, list=15%, signal=41%","MXI1/GYPA/CSF1/NFATC2/IL1B/CIITA/IKZF1/NOTCH1/LYL1/FOS/ZNF835/VAV1/IRF5/IL6/CXCR4/STAT5A/CSF3/GATA1/GP9/IL1A/ITGA2B/THRB/CD34/TNXB/FLI1/LMO2/NCKAP1L/SPI1/GATA2"
"WP364","WP364","IL-6 signaling pathway",43,-0.601223554064732,-1.76855203436559,0.00468384074941452,0.0184997832056656,0.00985843710301915,3728,"tags=47%, list=15%, signal=39%","MAPK3/MAP2K4/JUNB/SOCS3/GAB1/AKT1/BCL2L1/GRB2/JAK1/VAV1/NCOA1/STAT3/IL6/IL6ST/MAPK1/PIK3R1/HCK/PRKCD/IL6R"
"WP3303","WP3303","RAC1/PAK1/p38/MMP2 Pathway",68,-0.568156096046623,-1.84262663906128,0.00472813238770686,0.0184997832056656,0.00985843710301915,3580,"tags=38%, list=15%, signal=33%","MAPK3/CTNNB1/TNIP1/MAPK14/NFKB1/FN1/ANGPTL1/AKT1/CASP7/MAPK9/GRB2/STAT5B/CRK/STAT3/STAT5A/MAPK1/FOXO1/NFKBIA/PIK3R1/NOS1/TEK/DOK2/RS1/ANGPT4/ANGPT1"
"WP1541","WP1541","Energy Metabolism",47,-0.56738906134756,-1.69977606938516,0.00476190476190476,0.0184997832056656,0.00985843710301915,5054,"tags=34%, list=21%, signal=27%","CAMK2G/SIRT1/GSK3B/PPARGC1B/MEF2D/MAPK14/PRKAB1/EP300/NCOA1/PPP3CC/RXRA/MEF2A/FOXO1/FOXO3/PPARG"
"WP1982","WP1982","Sterol Regulatory Element-Binding Proteins (SREBP) signalling",71,-0.575739856062364,-1.87499972021835,0.00488997555012225,0.0184997832056656,0.00985843710301915,4836,"tags=41%, list=20%, signal=33%","ACSS1/SP1/SCAP/SIRT1/ACACA/INS/FDFT1/PPARGC1B/FASN/SCD/MED15/IDI1/SREBF2/PRKAB1/NR1H2/LSS/INSIG1/AKT1/GPAM/SAR1A/CYP51A1/HMGCS1/PRKACA/HMGCR/LDLR/LPL/RBP4/PPARG"
"WP4205","WP4205","MET in type 1 papillary renal cell carcinoma",59,-0.549954819803464,-1.71011250062039,0.00488997555012225,0.0184997832056656,0.00985843710301915,4385,"tags=42%, list=18%, signal=35%","C8orf34/RAF1/MAP2K1/ELOA/MAPK3/ETS1/PAK4/PAK5/SOS2/GAB1/AKT1/CDKN1A/CRKL/GRB2/TFE3/ARAF/CRK/RAP1A/PIK3R3/STAT3/RAPGEF1/MAPK1/PIK3R1/JUN"
"WP4538","WP4538","Regulatory circuits of the STAT3 signaling pathway",78,-0.533002986817774,-1.76304079571372,0.00488997555012225,0.0184997832056656,0.00985843710301915,3960,"tags=41%, list=16%, signal=34%","CTF1/PDGFRA/CNTFR/PTPRC/MAPK3/PTPRD/MAPK14/SOCS3/MAPK7/LIFR/IL11RA/MAPK9/CSF2RB/JAK1/MAPK4/CSF3R/IL2RG/STAT3/IL6ST/PRKCB/IL10RA/AGTR2/MAPK1/GHR/IFNLR1/IL3RA/IL20RA/IL7R/IL6R/F2RL3/AGTR1"
"WP428","WP428","Wnt Signaling",115,-0.460205606485278,-1.63752085375515,0.00490196078431373,0.0184997832056656,0.00985843710301915,5162,"tags=42%, list=21%, signal=33%","FZD8/RAC1/PPP3CB/CAMK2G/CHD8/WNT2B/GSK3B/LRP6/CCND1/DAAM1/NOTUM/SOST/WNT2/TCF7L1/NFATC2/CTNNB1/FZD1/APC/CCND2/ROCK2/WNT7A/SFRP5/MAPK9/TCF7L2/NFATC1/FRAT1/FZD7/CTNNBIP1/RHOA/FZD5/PPP3CC/CAMK2A/ROR1/DKK2/PRKCB/NFATC3/PRICKLE1/GPC4/DAAM2/JUN/SOX17/PLCB2/NKD2/CCND3/PRICKLE2/WNT3A/NKD1"
"WP4321","WP4321","Thermogenesis",108,-0.472966706268173,-1.66119186812598,0.00491400491400491,0.0184997832056656,0.00985843710301915,3860,"tags=28%, list=16%, signal=23%","MAP2K3/ADRB3/ARID1A/ADCY5/SMARCD3/PNPLA2/MAPK14/PRKAB1/SOS2/ACSL5/PRDM16/RPS6KA1/GRB2/ACSL4/CPT1A/SLC25A20/KLB/PRKACA/ADCY4/ADCY9/PRKG1/SMARCA2/ACSL1/MGLL/RPS6KA2/CNR1/PPARG/PRKG2/NPR1"
"WP673","WP673","ErbB Signaling Pathway",91,-0.50746055745121,-1.71751967058708,0.005,0.0186046511627907,0.00991432068543452,4412,"tags=37%, list=18%, signal=31%","GSK3B/PLCG1/CCND1/RAF1/MAP2K1/MAPK3/MAP2K4/CDKN1B/PAK4/PLCG2/PAK5/SOS2/GAB1/AKT1/HBEGF/ERBB4/MAPK9/CDKN1A/CRKL/SHC3/GRB2/STAT5B/ARAF/CRK/PIK3R3/CAMK2A/STAT5A/PRKCB/MAPK1/FOXO1/PIK3R1/JUN/NRG3"
"WP26","WP26","Signal Transduction of S1P Receptor",25,-0.682006331746115,-1.78248631708789,0.00683371298405467,0.0241545893719807,0.0128718535469108,3558,"tags=48%, list=15%, signal=41%","S1PR2/MAPK7/AKT1/MAPK4/GNAI1/S1PR5/MAPK1/ASAH1/GNAI2/PLCB2/S1PR1"
"WP465","WP465","Tryptophan metabolism",42,-0.568462525644927,-1.66828060658117,0.00683371298405467,0.0241545893719807,0.0128718535469108,4138,"tags=40%, list=17%, signal=34%","ACAT1/CYP1A1/ALDH3A2/ALDH1A1/WARS/IDO1/HAAO/ALDH2/OGDH/ALDH1A2/DHCR24/AOX1/CYP1A2/CAT/MAOB/INMT"
"WP4496","WP4496","Signal transduction through IL1R",33,-0.607456486490543,-1.69612466333712,0.00691244239631336,0.0241545893719807,0.0128718535469108,5125,"tags=61%, list=21%, signal=48%","MAP3K14/CHUK/RELA/TRAF6/MAP2K3/TAB1/MAPK14/TGFB2/NFKB1/IL1B/TGFB1/TOLLIP/IL1R1/IL6/IL1A/NFKBIA/IRAK3/JUN/MYD88"
"WP363","WP363","Wnt Signaling Pathway",51,-0.558895422142045,-1.70696125777929,0.00696055684454756,0.0241545893719807,0.0128718535469108,3489,"tags=43%, list=14%, signal=37%","LRP6/CCND1/TCF4/NFATC2/CTNNB1/APC/AKT1/MAPK9/TCF7L2/FRAT1/GJA1/RHOA/ROR1/PI4K2A/PRKCB/ARRB2/MAPK1/TEK/PIP5K1B/AXIN2/PPARG"
"WP3680","WP3680","Association Between Physico-Chemical Features and Toxicity Associated Pathways",66,-0.493591530412936,-1.58893128196474,0.00696055684454756,0.0241545893719807,0.0128718535469108,4412,"tags=42%, list=18%, signal=35%","PLCG1/DAAM1/RAF1/MAP2K1/CTNNB1/FZD1/MAP2K4/TMSB4X/CAMK1/CDKN1B/APC/FN1/ROCK2/AKT1/ERBB4/CDKN1A/GRB2/FZD7/RHOA/FZD5/STAT5A/MAPK1/JUN/MYLK/FZD4/NOS1/GRIA1"
"WP2525","WP2525","Trans-sulfuration and one carbon metabolism",31,0.619974131511702,1.66092493808102,0.00706713780918728,0.0241545893719807,0.0128718535469108,5937,"tags=55%, list=24%, signal=41%","DNMT3B/PSAT1/GCLC/TYMS/GCLM/MTHFD2L/CTH/PSPH/MTHFD2/BHMT/DHFR/SHMT2/DNMT3A/MAT1A/DNMT3L/CBS/DNMT1"
"WP585","WP585","Interferon type I signaling pathways",54,-0.512799005748204,-1.5738123030745,0.00707547169811321,0.0241545893719807,0.0128718535469108,3823,"tags=33%, list=16%, signal=28%","PTPRC/MAPK14/FYN/SOCS3/CRKL/JAK1/CRK/RAP1A/VAV1/IRS1/STAT3/STAT5A/PTPN6/RAPGEF1/PIAS1/PIK3R1/GAB2"
"WP4534","WP4534","Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms",47,-0.553002892571109,-1.65667818984855,0.00714285714285714,0.0241545893719807,0.0128718535469108,4886,"tags=43%, list=20%, signal=34%","ACTC1/TEAD1/TEAD4/MAPK10/TEAD3/MAP4K1/ITGB7/ACTA2/CTNNB1/CTNNA1/ITGB6/PAK4/PAK5/MAPK9/MAP4K2/ITGB2/SAV1/LIMD1/SGMS1"
"WP61","WP61","Notch Signaling Pathway",61,-0.50872642550276,-1.60237771110551,0.00717703349282297,0.0241545893719807,0.0128718535469108,5901,"tags=51%, list=24%, signal=39%","NCOR1/HEY2/SNW1/MAML2/PSEN2/DLL4/JAK2/NCSTN/SKP1/ADAM17/GSK3B/NCOR2/NOTCH2/CCND1/NFKB1/PSEN1/EP300/AKT1/NOTCH1/CDKN1A/GATA3/CIR1/STAT3/HEY1/NUMB/PIK3R1/APH1B/NOTCH4/PTCRA/FHL1"
"WP558","WP558","Complement and Coagulation Cascades",58,-0.517764904303038,-1.60778753824715,0.0072463768115942,0.0241545893719807,0.0128718535469108,1588,"tags=34%, list=7%, signal=32%","C3/C1QC/C3AR1/SERPINF2/SERPINA1/C1QA/C4B/THBD/C7/F8/C1QB/SERPIND1/SERPING1/CFD/C5AR1/VWF/MASP1/PROS1/CPB2"
"WP710","WP710","DNA Damage Response (only ATM dependent)",111,-0.421948465844916,-1.4909399130155,0.00738916256157635,0.0243642454697731,0.0129835781779712,3454,"tags=32%, list=14%, signal=27%","TCF7L1/CTNNB1/CDKN1B/NFKB1/APC/CCND2/PTEN/SOS2/WNT7A/AKT1/MAPK9/BCL6/PPP2R5C/CDKN1A/TCF7L2/PCK2/SOD2/GRB2/FRAT1/RAC2/IRS1/TGFB1/PIK3R3/RHOA/PIK3C2G/MAPK1/PIK3R1/PIK3R5/JUN/FOXO3/LDLR/CCND3/WNT3A/CAT"
"WP15","WP15","Selenium Micronutrient Network",89,-0.463322668064958,-1.55866650168236,0.00753768844221105,0.0243642454697731,0.0129835781779712,3493,"tags=31%, list=14%, signal=27%","GGTLC1/FGG/NFKB1/IL1B/ABCA1/FGA/SELENON/SERPINA3/SOD2/DIO3/ICAM1/PTGS1/IL6/KMO/ALOX15B/GGTLC2/ALOX5AP/APOA1/GGT1/LDLR/SOD3/HBB/GPX3/HBA1/CAT/ALOX5/SELENOP"
"WP2328","WP2328","Allograft Rejection",89,-0.499394293978949,-1.68001526971948,0.00753768844221105,0.0243642454697731,0.0129835781779712,3134,"tags=40%, list=13%, signal=35%","CD40/C2/HLA-DMB/CD86/C3/CXCL12/HLA-DRB5/CASP7/IL2/HLA-DRB1/CD40LG/LRRK2/C1QC/TGFB1/C8B/HLA-DRA/C4A/HLA-DMA/HLA-DQA2/HLA-DQA1/PECR/IL1A/C1QA/C4B/HLA-G/HLA-DPB1/C7/HLA-E/C1QB/PRKCZ/C5/PRF1/HLA-DPA1/HLA-DOA/AGTR1"
"WP75","WP75","Toll-like Receptor Signaling Pathway",103,-0.47066931532722,-1.62692638985206,0.00775193798449612,0.0248062015503876,0.013219094247246,5196,"tags=42%, list=21%, signal=33%","TNF/RAC1/CCL5/CHUK/RELA/TIRAP/MAPK10/TRAF6/CCL4/IFNA14/RIPK1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/TLR7/MAP2K4/MAPK14/NFKB1/IL1B/TLR5/CD40/CD86/AKT1/MAPK9/FOS/TLR3/TOLLIP/MAP3K8/TLR2/PIK3R3/IRF5/IL6/MAPK1/NFKBIA/PIK3R1/PIK3R5/JUN/MYD88/TLR8/TLR4"
"WP3858","WP3858","Toll-like Receptor Signaling",31,-0.593909181131908,-1.64129979980801,0.00917431192660551,0.0286225402504472,0.0152528010545146,5024,"tags=45%, list=21%, signal=36%","RELA/TIRAP/TRAF6/TLR7/NFKB1/TLR5/TLR3/TOLLIP/TLR2/MAPK1/MYD88/TLR8/TLR4"
"WP244","WP244","Alpha 6 Beta 4 signaling pathway",33,-0.592696115235935,-1.65491112741854,0.00921658986175115,0.0286225402504472,0.0152528010545146,3558,"tags=39%, list=15%, signal=34%","MAPK14/GAB1/AKT1/LAMA2/GRB2/IRS1/RHOA/LAMB2/MAPK1/PIK3R1/LAMA3/PRKCD"
"WP2112","WP2112","IL17 signaling pathway",32,-0.600847580208362,-1.67140725664644,0.0092378752886836,0.0286225402504472,0.0152528010545146,5196,"tags=66%, list=21%, signal=52%","IL17B/MAP3K14/JAK2/RELA/IL17RB/SP1/TRAF6/GSK3B/CEBPB/IL17RE/MAPK3/NFKB1/TRAF3IP2/AKT1/JAK1/STAT3/MAPK1/CEBPD/IL17RA/IL17D"
"WP410","WP410","Exercise-induced Circadian Regulation",48,-0.541562832478487,-1.63667859285653,0.00930232558139535,0.0286225402504472,0.0152528010545146,3570,"tags=46%, list=15%, signal=39%","ARNTL/EIF4G2/CEBPB/TAB2/IDI1/TOB1/GSTM3/CRY1/GFRA1/BTG1/DAZAP2/PPP2CB/QKI/HLA-DMA/RBPMS/PER1/NCOA4/CRY2/PPP1R3C/CLDN5/KLF9"
"WP2118","WP2118","Arrhythmogenic Right Ventricular Cardiomyopathy",74,-0.477962319992754,-1.57337705473479,0.00952380952380952,0.0290249433106576,0.0154672395273899,3848,"tags=42%, list=16%, signal=35%","CACNG2/TCF7L1/CTNNA3/CTNNB1/ITGA1/CTNNA1/CACNG4/ITGB6/CACNA1C/CACNA1D/CACNB4/SLC8A1/DAG1/SGCB/LAMA2/CACNA2D2/TCF7L2/SGCD/DMD/ITGA3/ACTN4/GJA1/ITGA9/ITGA10/ITGA2B/ACTN2/CACNA1S/SGCA/SGCG/ITGA8"
"WP2261","WP2261","Signaling Pathways in Glioblastoma",82,-0.46980885475768,-1.56855575596006,0.00995024875621891,0.0300384868112269,0.0160073515244038,3823,"tags=40%, list=16%, signal=34%","PDPK1/RAF1/MAP2K1/PDGFRA/MAPK3/MAP2K4/CDKN1B/CCND2/PTEN/PLCG2/EP300/GAB1/AKT1/MAP2K5/CDKN1A/GRB2/ARAF/IRS1/PIK3C2G/PRKCQ/PRKCB/MAPK1/FOXO1/FGFR2/FOXO4/PIK3R1/PRKCZ/FOXO3/PRKCD/SPRY2/PRKCH/CDKN2B"
"WP4263","WP4263","Pancreatic adenocarcinoma pathway",89,-0.448736434831178,-1.50959686901757,0.0100502512562814,0.0300568261870098,0.0160171244812355,3731,"tags=39%, list=15%, signal=33%","RAC1/CHUK/RELA/SMAD4/MAPK10/DDB2/CCND1/RAF1/MAP2K1/MAPK3/TGFB2/NFKB1/RALBP1/PAK4/PAK5/AKT1/BCL2L1/MAPK9/CDKN1A/JAK1/ARAF/RAC2/TGFB1/PIK3R3/RHOA/STAT3/PEBP1/MAPK1/PIK3R1/PRKCD/DUSP6/ARHGEF6/GADD45B/TGFBR2"
"WP1433","WP1433","Nucleotide-binding Oligomerization Domain (NOD) pathway",41,-0.540170731284649,-1.57711241728712,0.0114678899082569,0.033822348116518,0.0180237512989339,5235,"tags=46%, list=22%, signal=36%","CARD8/RAC1/CHUK/RELA/NLRP12/NLRP3/NOD2/PYCARD/IL1B/CASP5/CASP7/CARD9/MEFV/CASP1/NOD1/NFKBIA/CARD6/NLRC4"
"WP3676","WP3676","BDNF-TrkB Signaling",33,-0.57433990094298,-1.60365736936312,0.0115207373271889,0.033822348116518,0.0180237512989339,2738,"tags=42%, list=11%, signal=38%","TRPC3/MAP2K1/GAB1/AKT1/RPS6KA1/GRB2/MKNK1/MAPK1/NTRK2/GAB2/BDNF/ARC/TRPC6"
"WP4396","WP4396","Nonalcoholic fatty liver disease",155,-0.362936694457218,-1.32971578290757,0.0129533678756477,0.0376825247291569,0.0200808190990902,3164,"tags=15%, list=13%, signal=14%","NFKB1/IL1B/PRKAB1/MAP3K11/AKT1/ERN1/CASP7/MAPK9/IRS1/TGFB1/PIK3R3/COX7A1/IL6/RXRA/IL1A/ADIPOR2/PIK3R1/JUN/SMAD7/CEBPA/IL6R/COX4I2/LEPR"
"WP167","WP167","Eicosanoid Synthesis",26,-0.634788780537419,-1.6851790590273,0.0136363636363636,0.0387174833635814,0.0206323431082243,3378,"tags=46%, list=14%, signal=40%","PTGIS/PLA2G5/PTGS1/ALOX15B/GGTLC2/ALOX5AP/GGT1/LTA4H/TBXAS1/PTGDS/ALOX5"
"WP205","WP205","IL-7 Signaling Pathway",25,-0.647064231955439,-1.69116192335721,0.0136674259681093,0.0387174833635814,0.0206323431082243,4412,"tags=68%, list=18%, signal=56%","CCND1/MAP2K1/MAPK3/CDKN1B/FYN/AKT1/BCL2L1/STAT5B/JAK1/IL2RG/STAT3/STAT5A/PTK2B/MAPK1/PIK3R1/IL7R"
"WP2586","WP2586","Aryl Hydrocarbon Receptor",45,-0.518898697111699,-1.54927455814743,0.0137931034482759,0.0387174833635814,0.0206323431082243,4322,"tags=40%, list=18%, signal=33%","CYP1B1/CYP1A1/RAF1/MAP2K1/NFE2L2/CDKN1B/NFKB1/EP300/CDKN1A/ARNT/HPGDS/MAPK1/PLAGL1/LPL/KLF6/CYP1A2/CD36"
"WP268","WP268","Notch Signaling",45,-0.517665468318334,-1.54559250998549,0.0137931034482759,0.0387174833635814,0.0206323431082243,2384,"tags=24%, list=10%, signal=22%","NOTCH1/DTX4/NUMB/APH1B/INPP5K/KAT2B/NOTCH4/PTCRA/MFNG/KCNJ5"
"WP3863","WP3863","T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection",62,-0.472479499049397,-1.4986947424136,0.013986013986014,0.0389176041349954,0.0207389864140436,5125,"tags=48%, list=21%, signal=38%","MAP3K14/CHUK/CD8A/GSK3B/PLCG1/ICOS/RAF1/MAP2K1/PTPRC/MAPK3/LCP2/NFATC2/FYN/NFKB1/CHP1/AKT1/MAPK9/IL2/FOS/CD40LG/GRB2/CALM1/MAP3K8/PRKCQ/PTPN6/RRAS/NFKBIA/JUN/CD4"
"WP24","WP24","Peptide GPCRs",75,-0.45329305494355,-1.49817386341742,0.014218009478673,0.0392220951135807,0.0209012480539476,3865,"tags=35%, list=16%, signal=29%","NPY4R/HCRTR2/EDNRA/ATP8A1/GALR1/FPR3/SSTR1/NPY1R/GHSR/ACKR1/C3AR1/CCR1/CXCR4/CXCR1/AGTR2/AVPR2/CXCR2/TACR3/C5AR1/FPR1/SSTR4/FPR2/CX3CR1/AGTR1/EDNRB"
"WP176","WP176","Folate Metabolism",70,-0.464337196191892,-1.50408010089958,0.0146699266503667,0.0401228763086954,0.0213812696118706,3592,"tags=37%, list=15%, signal=32%","INS/MTHFS/CSF1/FOLR3/FGG/NFKB1/IL1B/ABCA1/FGA/FOLR1/FOLR2/IL2/SERPINA3/SOD2/SLC19A1/ICAM1/IL6/APOA1/LDLR/NOS1/SOD3/HBB/GPX3/HBA1/CAT"
"WP2858","WP2858","Ectoderm Differentiation",141,-0.369997509624108,-1.34987838598429,0.0151133501259446,0.040985356273748,0.0218408806458789,3453,"tags=27%, list=14%, signal=23%","CTNNB1/ARHGEF9/BCAS3/SNCA/GAS2L1/FYN/PI4KA/MECP2/CDON/SERPINB6/ABCC4/GLB1/ZBTB16/NFATC1/CDH6/DMD/ZNF219/BMP4/TSC22D1/PGM1/EDA/PLXNA2/NR2F2/FZD5/PLCXD3/BMPR1A/SOCS2/RAB8B/FGFR2/PTPRB/PTPN13/FZD4/SPRY2/CTNND2/SDCBP/GATA6/LDB2"
"WP1528","WP1528","Physiological and Pathological Hypertrophy of the Heart",25,-0.634959122979062,-1.6595241069428,0.0159453302961276,0.0427046263345196,0.0227570706124742,3906,"tags=56%, list=16%, signal=47%","MAP2K3/MAPK14/LIFR/FOS/CALM1/RHOA/STAT3/IL6ST/PRKCB/MAPK1/JUN/PRKCE/EDN1"
"WP2516","WP2516","ATM Signaling Pathway",40,0.554957330191489,1.55676315483946,0.0160142348754448,0.0427046263345196,0.0227570706124742,4611,"tags=42%, list=19%, signal=34%","CDC25C/CCNB1/CHEK1/CDK1/FANCD2/BRCA1/RAD51/CCNE1/CDC25A/MDM4/H2AFX/CHEK2/PIDD1/AP3B2/GADD45A/ATM/MRE11"
"WP4216","WP4216","Chromosomal and microsatellite instability in colorectal cancer ",73,-0.454120807285491,-1.48751379329662,0.0169491525423729,0.0448242050707382,0.0238865829653276,4776,"tags=42%, list=20%, signal=34%","RAC1/SMAD4/MAPK10/GSK3B/DDB2/CCND1/RAF1/MAP2K1/MLH1/MAPK3/TCF7L1/CTNNB1/TGFB2/APC/AKT1/MAPK9/APPL1/CDKN1A/TCF7L2/FOS/ARAF/RAC2/TGFB1/RHOA/MAPK1/JUN/DCC/GADD45B/AXIN2/TGFBR2"
"WP2036","WP2036","TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway",42,-0.514025556221922,-1.50852312693655,0.0182232346241458,0.0473512873631252,0.0252332518185075,5196,"tags=55%, list=21%, signal=43%","TNF/RAC1/CCL5/MAP3K14/CHUK/RELA/GSK3B/TRIM63/RIPK1/RAF1/MAPK3/CTNNB1/MAPK14/NFKB1/AKT1/CASP7/MAPK9/IL6/TNFSF12/MAPK1/NFKBIA/JUN"
"WP3594","WP3594","Circadian rhythm related genes",200,-0.350218594169658,-1.32383047067144,0.0182767624020888,0.0473512873631252,0.0252332518185075,3897,"tags=26%, list=16%, signal=22%","OPRL1/DYRK1A/ADORA2A/ID2/GNA11/HCRTR2/NAGLU/NKX2-1/RORB/PER3/PML/PTEN/CST3/ROCK2/EGR1/FBXW11/CRH/EP300/BTBD9/CRY1/KLF10/MAPK9/ID3/OPN3/JUND/NFIL3/UBC/HNF1B/ARNT/FBXL3/CPT1A/CARTPT/IL6/ARNT2/SFTPC/NTRK3/AGRP/CHRM1/PER1/SIK1/JUN/HEBP1/CRY2/PRF1/BHLHE41/GNAQ/PTGDS/PPARG/ID4/KLF9/PRKG2/SLC6A4"
"WP430","WP430","Statin Pathway",31,-0.557914902741278,-1.54182768556289,0.018348623853211,0.0473512873631252,0.0252332518185075,3115,"tags=39%, list=13%, signal=34%","ABCA1/APOA5/CYP7A1/APOE/CETP/HMGCR/LRP1/APOC1/APOA1/LDLR/LPL"
"WP4535","WP4535","Envelope proteins and their potential roles in EDMD physiopathology",46,-0.505460594276532,-1.5219902451176,0.0186046511627907,0.0476279069767442,0.0253806609547124,5515,"tags=43%, list=23%, signal=34%","PLEC/SRF/ADCY3/SMAD4/ADCY8/MAP2K1/MAPK3/ADCY5/TGFB2/TMEM43/SOS2/GRB2/TGFB1/RHOA/CCN2/MAPK1/ADCY4/SYNE3/ADCY9"
1 ID Description setSize enrichmentScore NES pvalue p.adjust qvalues rank leading_edge core_enrichment
2 WP2446 WP2446 Retinoblastoma Gene in Cancer 87 0.636565973412448 2.07894768186214 0.00165837479270315 0.0136986301369863 0.00729992790194665 4697 tags=54%, list=19%, signal=44% TOP2A/ANLN/POLE2/KIF4A/CCNB1/CCNA2/TTK/CHEK1/PLK4/MCM4/CCNB2/CDK1/RRM2/TYMS/CDC45/RFC4/CCNE2/ORC1/TFDP1/CCNE1/SKP2/CDT1/CDC25A/E2F2/CDC7/FANCG/MSH6/MCM6/BARD1/POLE/PRKDC/E2F3/SMC2/MCM7/RFC5/STMN1/DHFR/RFC3/RPA3/WEE1/HLTF/PRIM1/E2F1/HMGB2/PCNA/H2AFZ/MCM3
3 WP179 WP179 Cell Cycle 120 0.514478582141183 1.74942320154924 0.00166666666666667 0.0136986301369863 0.00729992790194665 4923 tags=38%, list=20%, signal=31% CDKN2A/CDC25C/CCNB1/CCNA2/TTK/CHEK1/CDC6/PLK1/ORC6/CDC20/MCM4/BUB1/CCNB2/CDK1/ESPL1/DBF4/CDC45/CCNE2/ORC1/PTTG1/TFDP1/MCM2/CCNE1/PKMYT1/SKP2/CDC25A/SMC1B/E2F2/CDC7/MCM6/PRKDC/E2F3/E2F5/CHEK2/MCM7/RBL1/CDKN2C/WEE1/GADD45A/E2F1/ORC2/PCNA/ATM/MCM3/ANAPC11/BUB3
4 WP4016 WP4016 DNA IR-damage and cellular response via ATR 80 0.608265656044446 1.96395220508954 0.00167785234899329 0.0136986301369863 0.00729992790194665 4611 tags=44%, list=19%, signal=36% CDC25C/BRIP1/CHEK1/PLK1/EXO1/FANCI/FOXM1/CDK1/CDC45/FANCD2/MSH2/FANCA/MCM2/BRCA1/RAD51/CLSPN/BRCA2/FEN1/TOPBP1/BARD1/POLB/PRKDC/EEF1E1/H2AFX/CHEK2/RMI1/CLK2/RBBP8/RFWD3/PALB2/E2F1/PCNA/SEM1/ATM/MRE11
5 WP2369 WP2369 Histone Modifications 67 0.622040510738319 1.9314019320563 0.00174825174825175 0.0136986301369863 0.00729992790194665 3552 tags=40%, list=15%, signal=34% EZH2/HIST1H4H/HIST1H4C/HIST1H3H/HIST1H4E/SUV39H2/HIST1H3B/HIST1H3J/HIST1H3D/HIST1H4D/HIST1H4I/HIST1H3C/HIST1H4B/HIST1H3F/EED/HIST1H4F/SMYD3/HIST1H4A/HIST1H3I/HIST1H4L/HIST1H3A/HIST4H4/HIST1H3G/HIST1H4J/HIST1H4K/KMT5C/SMYD5
6 WP466 WP466 DNA Replication 42 0.682437853191023 1.93537269381962 0.00177619893428064 0.0136986301369863 0.00729992790194665 4697 tags=57%, list=19%, signal=46% POLE2/CDC6/ORC6/MCM4/MCM10/DBF4/CDC45/RFC4/ORC1/MCM2/CDT1/GMNN/CDC7/MCM6/PRIM2/POLE/MCM7/RFC5/RFC3/RPA3/PRIM1/ORC2/PCNA/MCM3
7 WP2361 WP2361 Gastric Cancer Network 1 29 0.686964138085659 1.80275060612194 0.00178890876565295 0.0136986301369863 0.00729992790194665 3244 tags=52%, list=13%, signal=45% CENPF/TOP2A/TPX2/UBE2C/ECT2/E2F7/MCM4/MYBL2/KIF15/AURKA/KIF20B/S100P/RUVBL1/HIST4H4/ACTL6A
8 WP357 WP357 Fatty Acid Biosynthesis 22 -0.726399194516133 -1.84886866105561 0.00223713646532438 0.0136986301369863 0.00729992790194665 4344 tags=64%, list=18%, signal=52% ECH1/ACACA/ECHDC1/FASN/SCD/ACSL5/ACAA2/ACSL4/DECR1/PECR/ACSS2/ACACB/ACSL1
9 WP545 WP545 Complement Activation 22 -0.756514524093489 -1.92551974973147 0.00223713646532438 0.0136986301369863 0.00729992790194665 2934 tags=59%, list=12%, signal=52% C3/C1QC/C8B/C4A/C1QA/C4B/C7/C1QB/CFP/C5/CFD/MASP1
10 WP127 WP127 IL-5 Signaling Pathway 40 -0.642749664204508 -1.87301769330181 0.00227272727272727 0.0136986301369863 0.00729992790194665 3731 tags=52%, list=15%, signal=45% SYK/GSK3B/RAF1/MAP2K1/MAPK3/AKT1/IL2/RPS6KA1/FOS/GRB2/CSF2RB/STAT5B/JAK1/STAT3/STAT5A/MAPK1/PIK3R1/JUN/FOXO3/BTK
11 WP3937 WP3937 Microglia Pathogen Phagocytosis Pathway 40 -0.693804651206547 -2.02179551351968 0.00227272727272727 0.0136986301369863 0.00729992790194665 3031 tags=55%, list=12%, signal=48% FCGR1A/NCF4/PLCG2/C1QC/VAV1/RAC2/ITGB2/SIGLEC7/PIK3R3/FCER1G/TREM1/PTPN6/C1QA/CYBB/PIK3R1/C1QB/HCK/NCF1/ITGAM/NCKAP1L/NCF2
12 WP49 WP49 IL-2 Signaling Pathway 42 -0.654594269333697 -1.92105350035104 0.00227790432801822 0.0136986301369863 0.00729992790194665 3731 tags=55%, list=15%, signal=46% MAP2K1/MAPK3/CISH/FYN/SOCS3/CCND2/AKT1/IL2/CRKL/FOS/GRB2/STAT5B/JAK1/IL2RG/STAT3/STAT5A/PTK2B/MAPK1/PIK3R1/JUN/FOXO3/GAB2
13 WP1539 WP1539 Angiogenesis 24 -0.732880961801299 -1.89749435748104 0.00229357798165138 0.0136986301369863 0.00729992790194665 4385 tags=62%, list=18%, signal=51% FLT1/PDGFRA/TIMP2/MAPK14/AKT1/ARNT/KDR/MAPK1/FGFR2/TIMP3/TEK/FGF2/PDGFB/ANGPT1
14 WP98 WP98 Prostaglandin Synthesis and Regulation 45 -0.67707967450932 -2.02155511161406 0.00229885057471264 0.0136986301369863 0.00729992790194665 3864 tags=60%, list=16%, signal=51% PPARGC1B/EDNRA/ANXA2/ANXA4/PRL/TBXA2R/PTGIS/SCGB1A1/ABCC4/PTGER3/PTGFR/ANXA6/HSD11B1/PTGS1/HPGDS/HPGD/PTGER2/MITF/PTGIR/PTGER4/ANXA3/TBXAS1/PTGDS/PPARG/EDN1/EDNRB
15 WP4481 WP4481 Resistin as a regulator of inflammation 33 -0.728719111343713 -2.03471110257775 0.00230414746543779 0.0136986301369863 0.00729992790194665 5951 tags=67%, list=25%, signal=50% IKBKG/PLCD3/PLCB4/AKT3/TNF/CHUK/RELA/PLCG1/MAPK3/MAPK14/NFKB1/PLCG2/AKT1/ITPR1/IL6/PLCD1/MAPK1/RETN/PLCE1/NFKBIA/PLCB2
16 WP4149 WP4149 White fat cell differentiation 32 -0.717187214869053 -1.99503493862868 0.0023094688221709 0.0136986301369863 0.00729992790194665 4991 tags=75%, list=21%, signal=60% EBF1/RORA/CEBPB/INS/TLE3/TCF7L1/CTNNA1/EGR2/NR3C1/STAT5B/KLF4/RARA/NR2F2/GATA3/ZNF423/STAT5A/FOXO1/CEBPD/KLF2/CEBPA/KLF15/GATA2/PPARG
17 WP3942 WP3942 PPAR signaling pathway 67 -0.635560220456832 -2.05978992655891 0.00232558139534884 0.0136986301369863 0.00729992790194665 2954 tags=37%, list=12%, signal=33% CYP7A1/ACSL5/HMGCS2/ACAA1/PCK2/ACSL4/ILK/CPT1A/RXRA/SLC27A6/FABP1/APOA1/ACSL1/LPL/FABP3/SORBS1/ACADL/OLR1/PPARG/RXRG/FABP5/FABP4/CYP27A1/CD36
18 WP4155 WP4155 Endometrial cancer 63 -0.670921336651483 -2.1426216377604 0.00232558139534884 0.0136986301369863 0.00729992790194665 4412 tags=46%, list=18%, signal=38% DDB2/CCND1/PDPK1/RAF1/MAP2K1/MAPK3/TCF7L1/CTNNA3/CTNNB1/CTNNA1/APC/PTEN/SOS2/AKT1/CDKN1A/TCF7L2/FOS/GRB2/ARAF/ILK/PIK3R3/MAPK1/FGFR2/PIK3R1/FOXO3/FGF2/GADD45B/AXIN2
19 WP2637 WP2637 Structural Pathway of Interleukin 1 (IL-1) 49 -0.644842291521501 -1.94927613450899 0.00233100233100233 0.0136986301369863 0.00729992790194665 5196 tags=55%, list=21%, signal=43% MAP3K14/CHUK/RELA/MAPK10/TRAF6/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/MAP2K4/MAPK14/NFKB1/MAPK9/FOS/TOLLIP/MKNK1/MAP3K8/IL1R1/MKNK2/IL1A/MAPK1/MBP/NFKBIA/MYD88/MAP3K3
20 WP286 WP286 IL-3 Signaling Pathway 49 -0.763650610847904 -2.30841855504975 0.00233100233100233 0.0136986301369863 0.00729992790194665 3731 tags=59%, list=15%, signal=50% MAP2K1/MAPK3/FYN/YWHAB/CD86/AKT1/BCL2L1/CD69/INPP5D/CRKL/FOS/GRB2/CSF2RB/STAT5B/JAK1/VAV1/TGFB1/STAT3/STAT5A/PRKACA/PTPN6/RAPGEF1/MAPK1/PIK3R1/JUN/HCK/GAB2/IL3RA
21 WP4249 WP4249 Hedgehog Signaling Pathway 43 -0.655625827604928 -1.92858111322179 0.00234192037470726 0.0136986301369863 0.00729992790194665 4544 tags=42%, list=19%, signal=34% SHH/CCND1/PTCH1/DHH/GPR161/CDON/CCND2/SUFU/EVC/FBXL17/SPOP/PRKACA/GRK3/ARRB2/LRP2/HHIP/ARRB1
22 WP395 WP395 IL-4 Signaling Pathway 54 -0.658040267101942 -2.01956684134443 0.00235849056603774 0.0136986301369863 0.00729992790194665 3558 tags=52%, list=15%, signal=44% MAPK14/SOCS3/NFKB1/FES/IL4R/EP300/AKT1/STAT6/INPP5D/FOS/GRB2/FLNA/STAT5B/JAK1/IRS1/NFIL3/GATA3/IL2RG/STAT3/STAT5A/PTPN6/MAPK1/NFKBIA/PIK3R1/GAB2/CEBPA/DOK2
23 WP195 WP195 IL-1 signaling pathway 55 -0.64272055450148 -1.98054641301281 0.00237529691211401 0.0136986301369863 0.00729992790194665 5196 tags=56%, list=21%, signal=44% NFKBIB/MAP3K14/CHUK/RELA/SQSTM1/TRAF6/PLCG1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/MAP2K4/MAPK14/NFKB1/IL1B/AKT1/MAPK9/TOLLIP/IL1R1/IL1A/HSPB2/MAPK1/NFKBIA/IRAK3/PIK3R1/JUN/MYD88/MAP3K3/PRKCZ
24 WP2572 WP2572 Primary Focal Segmental Glomerulosclerosis FSGS 72 -0.564895810605214 -1.85209517787765 0.00237529691211401 0.0136986301369863 0.00729992790194665 4385 tags=49%, list=18%, signal=40% CTSL/LRP6/VIM/NPHS2/CR1/CD151/CTNNB1/CDKN1B/FYN/MYH9/COL4A5/AKT1/DAG1/NOTCH1/CDKN1A/COL4A3/ITGA3/SCARB2/ACTN4/TGFB1/ILK/UTRN/PARVA/VCL/LAMB2/TLN1/MME/CDKN1C/PLCE1/PTPRO/TLR4/TRPC6/SYNPO/COL4A4
25 WP2795 WP2795 Cardiac Hypertrophic Response 55 -0.562491502261919 -1.73332021101943 0.00237529691211401 0.0136986301369863 0.00729992790194665 5125 tags=53%, list=21%, signal=42% RAC1/MAP3K14/CHUK/GSK3B/MAP4K1/MAP2K3/PDPK1/RAF1/MAP2K1/TNFRSF1A/MAPK3/NFATC2/MAP2K4/MAPK14/HDAC5/NFKB1/MAPK7/AKT1/MAP2K5/HDAC7/CALM1/TGFB1/MEF2A/MAPK1/FGFR2/PRKG1/FGF2/PRKD1
26 WP560 WP560 TGF-beta Receptor Signaling 55 -0.618128504062653 -1.90476589386786 0.00237529691211401 0.0136986301369863 0.00729992790194665 3558 tags=47%, list=15%, signal=40% RUNX3/CTNNB1/THBS1/ITGB6/NFKB1/FKBP1A/ZEB2/EP300/MAPK9/FOS/TFE3/JAK1/TGFB1/BMP4/SKI/STAT3/ZNF423/ZFYVE9/JUN/LEFTY2/SMAD7/ENG/TGFBR2/TGFBR3/SMAD6
27 WP2203 WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 47 -0.678806935318986 -2.03356014944586 0.00238095238095238 0.0136986301369863 0.00729992790194665 3758 tags=51%, list=15%, signal=43% MAP2K1/MAPK3/CISH/MAPK14/FYN/NFKB1/FES/AKT1/MAPK9/STAT6/STAT5B/JAK1/STAT3/IL6/STAT5A/TSLP/PI4K2A/MAPK1/NFKBIA/HCK/GAB2/IL7R/BTK
28 WP2034 WP2034 Leptin signaling pathway 76 -0.60032634434338 -1.98738947622487 0.00239234449760766 0.0136986301369863 0.00729992790194665 5087 tags=54%, list=21%, signal=43% CHUK/JAK2/RELA/SP1/GSK3B/PLCG1/ACACA/CCND1/CFL2/RAF1/MAP2K1/MAPK3/CISH/MAPK14/PDE3B/FYN/SOCS3/NFKB1/IL1B/ROCK1/PTEN/ROCK2/PLCG2/AKT1/BCL2L1/RPS6KA1/GRB2/STAT5B/JAK1/IRS1/NCOA1/RHOA/STAT3/SOCS2/MAPK1/FOXO1/PIK3R1/PTPN1/ACACB/LEPR
29 WP2037 WP2037 Prolactin Signaling Pathway 76 -0.614835273428521 -2.03542150621455 0.00239234449760766 0.0136986301369863 0.00729992790194665 3758 tags=42%, list=15%, signal=36% RAF1/MAP2K1/MAPK3/CISH/MAPK14/FYN/SOCS3/NFKB1/PRL/AKT1/MAPK9/FOS/GRB2/FLNA/STAT5B/JAK1/VAV1/IRS1/CTSD/STAT3/STAT5A/SOCS2/PTPN6/MAPK1/NFKBIA/PIK3R1/JUN/PTPN1/GAB2/SIRPA/RPS6KA2
30 WP3945 WP3945 TYROBP Causal Network 61 -0.729451463583409 -2.29761362489514 0.00239234449760766 0.0136986301369863 0.00729992790194665 3574 tags=57%, list=15%, signal=49% TYROBP/ELF4/PYCARD/RUNX3/GIMAP2/IL13RA1/ABCC4/ZFP36L2/RNASE6/CAPG/SH2B3/C3/PLEK/LYL1/RPS6KA1/NRROS/C1QC/ITGB2/SLC7A7/HCLS1/HLX/GAPT/STAT5A/CXCL16/FKBP15/IL10RA/CD4/APBB1IP/ITGAM/NCKAP1L/BIN2/ITGAX/NCF2/CD37
31 WP304 WP304 Kit receptor signaling pathway 59 -0.701221359646638 -2.18048350455823 0.00244498777506112 0.0136986301369863 0.00729992790194665 3758 tags=51%, list=15%, signal=43% RAF1/MAP2K1/MAPK3/DOK1/MAPK14/JUNB/FYN/EP300/AKT1/RPS6KA1/MATK/INPP5D/CRKL/FOS/GRB2/STAT5B/CRK/VAV1/STAT3/STAT5A/PRKCB/PTPN6/MAPK1/PIK3R1/FOXO3/MITF/GAB2/BTK/TBX2
32 WP4341 WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 71 -0.655504539161554 -2.13476766388158 0.00244498777506112 0.0136986301369863 0.00729992790194665 3689 tags=46%, list=15%, signal=40% MAPK3/ETS1/MAPK14/NFKB1/CD40/MAPK7/PLCG2/DEFB4A/MAPK9/CD40LG/JAK1/TLR2/IL6/CAMK2A/PRKCQ/RXRA/PRKCB/RSAD2/PLCD1/MAPK1/PLCE1/JUN/TLR8/PRKCZ/PRKCD/PLCB2/OAS2/TLR4/PRKCH/PRKCE/RXRG/CAV1
33 WP4298 WP4298 Viral Acute Myocarditis 84 -0.639586276038619 -2.14233412609757 0.00245700245700246 0.0136986301369863 0.00729992790194665 3558 tags=50%, list=15%, signal=43% MICA/EIF4G2/GSK3B/AIF1/CCND1/MAPK3/PYCARD/FYN/TLR5/AKT1/DAG1/SGCB/BCL2L1/CASP7/LAMA2/IL2/CD40LG/SGCD/JAK1/DMD/TLR3/RAC2/ITGB2/TGFB1/HLA-DMA/BNIP2/STAT3/IL6/CXCR4/CASP1/MAPK1/PIK3R1/CD4/NOS1/TLR4/ITGAL/PTCRA/SGCA/EDN1/SGCG/CAV1
34 WP23 WP23 B Cell Receptor Signaling Pathway 97 -0.612444610670313 -2.10875866219875 0.00246913580246914 0.0136986301369863 0.00729992790194665 3932 tags=48%, list=16%, signal=41% MAX/PDPK1/TEC/RAF1/MAP2K1/MEF2D/PTPRC/ETS1/NFATC2/PIK3AP1/MAPK14/PTPN18/FYN/NFKB1/PLCG2/GAB1/AKT1/PIP5K1C/MAPK9/BCL6/RPS6KA1/INPP5D/CRKL/GRB2/MAPK4/CRK/VAV1/RAC2/CD81/HCLS1/CAMK2A/PRKCB/NFATC3/PTPN6/RAPGEF1/MAPK1/FOXO1/NFKBIA/CD22/PIK3R1/JUN/KLF11/PRKCD/GAB2/BTK/PIP5K1B
35 WP2806 WP2806 Human Complement System 97 -0.642923121630133 -2.21370174256498 0.00246913580246914 0.0136986301369863 0.00729992790194665 3341 tags=44%, list=14%, signal=38% THBS1/FGG/FGA/CD40/C2/SELL/C3/FCN1/ITGB2/ICAM1/TLR2/C4A/DCN/C3AR1/PRKACA/FCGR3A/ITGA2B/ARRB2/CD93/C7/APOA1/GNAI2/CFP/F11/WAS/C5/ICAM2/SELP/SFTPA1/SERPING1/CFD/C5AR1/SFTPA2/CLEC4M/LRP2/C4BPA/FPR1/VSIG4/SELPLG/ITGAX/MASP1/PROS1
36 WP3931 WP3931 ESC Pluripotency Pathways 117 -0.483215380726575 -1.72146078193607 0.00246913580246914 0.0136986301369863 0.00729992790194665 3823 tags=36%, list=16%, signal=30% RAF1/MAP2K1/PDGFRA/WNT2/CTNNB1/FZD1/APC/MAPK7/PTEN/GAB1/WNT7A/AKT1/MAP2K5/LIFR/PDGFA/FOS/GRB2/FGF18/JAK1/MAPK4/ARAF/FGF7/FZD7/BMP4/FGF10/FZD5/STAT3/BMPR1A/IL6ST/MAPK1/FGFR2/JUN/FZD4/SMAD7/FGFR4/BMPR2/FGF2/WNT3A/PDGFB/SMAD6/SELENOP
37 WP2431 WP2431 Spinal Cord Injury 119 -0.467420960589209 -1.66836001096026 0.00247524752475248 0.0136986301369863 0.00729992790194665 3188 tags=37%, list=13%, signal=32% ROS1/IL1B/PDYN/FKBP1A/ROCK2/EGR1/FCGR2A/FCGR2C/PTPRA/CXCL2/IL2/BTG2/PLA2G5/FOS/MAG/GJA1/TGFB1/ICAM1/IL1R1/PLXNA2/RHOA/IL6/ZFP36/IL1A/MAPK1/RHOB/MBP/AQP1/C1QB/TNFSF13/C5/FOXO3/SELP/SEMA6A/NOS1/LILRB3/LOC102725035/BDNF/TLR4/AQP4/SLIT3/EFNB2/SLIT2
38 WP366 WP366 TGF-beta Signaling Pathway 132 -0.478303442833193 -1.73180872054833 0.00247524752475248 0.0136986301369863 0.00729992790194665 4442 tags=45%, list=18%, signal=37% SKP1/TRAF6/ZEB1/APP/RBL2/CCND1/MAP4K1/MAP2K3/TAB1/RAF1/MAP2K1/FOSB/YAP1/PRKAR2A/ETS1/LIMK2/MAP2K4/MAPK14/THBS1/JUNB/ATF3/FN1/PML/ROCK1/ZEB2/TGFB1I1/EP300/AKT1/DCP1A/KLF10/MAPK9/CDKN1A/FOS/JUND/GRB2/MAPK4/WWP1/TGFB1/SKI/RHOA/MEF2A/MAPK1/ZFYVE9/NEDD4L/SIK1/DAB2/PIAS1/PIK3R1/JUN/SPTBN1/KLF11/NEDD9/SMAD7/KLF6/CDKN2B/TGFBR2/TGFBR3/CAV1
39 WP3915 WP3915 Angiopoietin Like Protein 8 Regulatory Pathway 132 -0.52741840164463 -1.9096408379071 0.00247524752475248 0.0136986301369863 0.00729992790194665 4412 tags=39%, list=18%, signal=32% MAPKAP1/CAP1/MAP3K4/MLXIPL/INS/MAP4K1/MAP2K3/FASN/PDPK1/SCD/RAF1/MAP2K1/MAPK3/FLOT2/MAP2K4/MAPK14/SREBF2/RHOQ/PRKAB1/MAPK7/MAP3K11/CYP7A1/MINK1/TRIP10/SOS2/AKT1/MAP2K5/MAPK9/RPS6KA1/SHC3/MAPK4/CRK/IRS1/MAP4K2/MAP3K8/PIK3R3/PIK3C2G/RXRA/MAP3K6/RAPGEF1/THRB/MAPK1/FOXO1/THRA/PIK3R1/PTPN1/MAP3K3/FOXO3/LPL/RPS6KA2/FBP1
40 WP1544 WP1544 MicroRNAs in cardiomyocyte hypertrophy 98 -0.544054587205048 -1.87677876598414 0.00248138957816377 0.0136986301369863 0.00729992790194665 3906 tags=39%, list=16%, signal=33% MAP2K3/TAB1/PDPK1/RAF1/MAP2K1/MAPK3/CISH/CTNNB1/FZD1/MAP2K4/MAPK14/HDAC5/NFKB1/ROCK1/MAPK7/ROCK2/AKT1/MAP2K5/RCAN1/HDAC7/CALM1/MAPK4/TGFB1/PIK3R3/RHOA/STAT3/IL6ST/PRKCB/MAPK1/FGFR2/PIK3R1/PRKG1/MYLK/PLCB2/FGF2/WNT3A/EDN1
41 WP236 WP236 Adipogenesis 130 -0.474985938357607 -1.7171574020515 0.00248138957816377 0.0136986301369863 0.00729992790194665 3747 tags=35%, list=15%, signal=30% MEF2D/CNTFR/CTNNB1/FZD1/SOCS3/EGR2/PTGIS/LIFR/KLF7/STAT6/ID3/CDKN1A/PCK2/NR3C1/STAT5B/IRS1/TGFB1/WWTR1/RARA/BMP4/NCOA1/GATA3/STAT3/IL6/STAT5A/RXRA/BMP2/IL6ST/MEF2A/RETN/FOXO1/CEBPD/FRZB/CFD/PLIN2/LPL/CEBPA/KLF15/KLF6/GDF10/GATA2/GADD45B/PPARG/RXRG/EPAS1
42 WP4540 WP4540 Pathways Regulating Hippo Signaling 98 -0.521323028062473 -1.79836364272296 0.00248138957816377 0.0136986301369863 0.00729992790194665 3799 tags=35%, list=16%, signal=29% GNA11/PDGFRA/PRKAR2A/TCF7L1/CTNNB1/CSF1R/PRKAB1/CDH9/FLT4/TCF7L2/PRKAR1A/CDH6/CDH10/RHOA/PRKCQ/PRKACA/CDH19/PRKCB/KDR/NTRK2/FGFR2/GNAI2/PRKCZ/LATS2/PRKCD/CDH13/FGFR4/PLCB2/TEK/PRKCH/PRKCE/GNAQ/CDH5
43 WP536 WP536 Calcium Regulation in the Cardiac Cell 149 -0.516859634478407 -1.89197755115013 0.00248138957816377 0.0136986301369863 0.00729992790194665 3912 tags=43%, list=16%, signal=36% GNG5/RGS19/PRKAR2B/ADRB3/GNA11/PRKAR2A/YWHAH/ADCY5/ATP2B3/RGS16/CAMK1/YWHAB/FKBP1A/RGS18/CACNA1C/RYR1/GNG2/PKIA/CACNA1D/SLC8A1/RGS2/PLN/GJA4/PRKAR1A/CALM1/GJA1/ANXA6/GNAI1/ITPR1/CAMK2A/PRKCQ/PRKACA/RGS6/CASQ2/PRKCB/PKIG/ARRB2/CHRM1/ADCY4/GJC2/ADCY9/GNAI2/ATP1B2/PRKCZ/GNG7/ADRA1A/SLC8A3/PRKCD/GJA5/RGS5/PRKCH/CACNA1S/ARRB1/PRKCE/PRKD1/ADRA1B/GNAQ/CHRM2/RGS9/ADRB1/ADRB2/KCNJ5/GRK5
44 WP138 WP138 Androgen receptor signaling pathway 90 -0.525276462659242 -1.77249607836137 0.00249376558603491 0.0136986301369863 0.00729992790194665 5087 tags=47%, list=21%, signal=37% RAC1/RELA/TLE5/KAT7/SMAD4/SIN3A/SP1/SIRT1/GSK3B/NCOR2/RNF6/CCND1/KAT5/LIMK2/CTNNB1/ROCK1/PTEN/ROCK2/TGFB1I1/DSTN/EP300/AKT1/RNF14/CDKN1A/FLNA/NCOA1/RHOA/STAT3/KLK3/ZMIZ1/FOXO1/RHOB/PIAS1/PIK3R1/JUN/NCOA4/AR/KAT2B/ETV5/PLPP1/CAV1
45 WP51 WP51 Regulation of Actin Cytoskeleton 151 -0.543185017975121 -1.9920987618635 0.00249376558603491 0.0136986301369863 0.00729992790194665 3827 tags=39%, list=16%, signal=33% CFL2/RAF1/MAP2K1/PDGFRA/MAPK3/ARHGAP35/PIP4K2B/SSH1/ITGA1/TMSB4X/APC/FN1/PAK4/ROCK1/ROCK2/CYFIP2/PAK5/SOS2/PIP5K1C/PDGFA/RRAS2/SSH2/FGF18/IQGAP1/MAPK4/CRK/VAV1/RAC2/FGF7/DIAPH1/EZR/PIK3R3/FGF10/RHOA/GSN/PIK3C2G/WASF2/VCL/RDX/CHRM1/MAPK1/RRAS/FGFR2/MYL3/PIK3R1/PIK3R5/SLC9A1/WAS/MYLK/MSN/MRAS/FGFR4/ARHGEF6/MYH10/FGF2/PDGFB/CHRM2/PIP5K1B
46 WP69 WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 90 -0.602333142752611 -2.03251660657157 0.00249376558603491 0.0136986301369863 0.00729992790194665 5173 tags=57%, list=21%, signal=45% GRAP2/SKAP1/MAP3K14/CHUK/RELA/CD8A/TRAF6/PLCG1/ICOS/VIM/MAP4K1/CD3E/PDPK1/RAF1/MAP2K1/MAPK3/LCP2/NFATC2/MAPK14/DBNL/FYN/NFKB1/IL1B/AKT1/SH2B3/MAPK9/CRKL/FOS/GRB2/NFATC1/CD247/CRK/VAV1/TGFB1/MAP3K8/ITPR1/GATA3/IL6/PRKCQ/IL1A/PTK2B/MAPK1/NFKBIA/CD83/PIK3R1/JUN/WAS/PRKCD/CD4/GAB2
47 WP4541 WP4541 Hippo-Merlin Signaling Dysregulation 121 -0.476114960490584 -1.70282708999761 0.0025 0.0136986301369863 0.00729992790194665 3848 tags=34%, list=16%, signal=29% PRKAR2B/PDGFRA/PRKAR2A/CTNNB1/ITGA1/CTNNA1/ITGB6/CSF1R/PAK4/CDH9/PAK5/AJUBA/FLT4/PRKAR1A/CDH6/ITGA3/ITGB2/ITGA9/CDH10/PRKACA/ITGAE/CDH19/CCN2/SAV1/KDR/ITGA10/ITGA2B/NTRK2/CD44/FGFR2/LATS2/CDH13/FGFR4/ITGAM/TEK/PPP1R14A/ITGAL/ITGAX/ITGA8/CDH5
48 WP231 WP231 TNF alpha Signaling Pathway 92 -0.508347384485388 -1.72409999242593 0.00251256281407035 0.0136986301369863 0.00729992790194665 5196 tags=41%, list=21%, signal=33% TNF/RAC1/MAP3K14/CHUK/PYGL/PPP2CA/SKP1/RIPK3/RIPK1/MAP2K3/TAB1/RAF1/TNFRSF1A/TNFRSF1B/TAB2/MAPK3/NSMAF/MAP2K4/NFKB1/FBXW11/AKT1/OTUD7B/BCL2L1/CASP7/MAPK9/CFLAR/GRB2/MAP4K2/TNFAIP3/MAP3K8/IL6/GLUL/MAPK1/NFKBIA/JUN/MAP3K3/PRKCZ
49 WP185 WP185 Integrin-mediated Cell Adhesion 102 -0.583190075319158 -2.02092896305995 0.00252525252525253 0.0136986301369863 0.00729992790194665 3848 tags=52%, list=16%, signal=44% ITGAD/MAPK10/DOCK1/CAPN9/PXN/CAPN3/VASP/ITGB7/MAP2K3/PDPK1/RAF1/MAP2K1/ITGA1/FYN/ITGB6/CAPN2/PAK4/ROCK1/MAPK7/ROCK2/CAPNS1/AKT1/MAP2K5/SHC3/GRB2/MAPK4/ARAF/CRK/RAP1A/ITGA3/RAC2/ITGB2/ILK/ITGA9/ZYX/ITGAE/VCL/RAPGEF1/ITGA10/ITGA2B/MAPK1/TLN1/CAV3/ITGAM/CAV2/SORBS1/ITGAL/ITGAX/TNS1/ITGA8/SELENOP/CAV1
50 WP399 WP399 Wnt Signaling Pathway and Pluripotency 102 -0.50786031199826 -1.75988868319521 0.00252525252525253 0.0136986301369863 0.00729992790194665 3454 tags=37%, list=14%, signal=32% TCF7L1/CTNNB1/FZD1/MAP2K4/CTNND1/APC/CCND2/EP300/WNT7A/MMP7/FBXW2/MAPK9/PPP2R5C/TCF7L2/LRRK2/FRAT1/PAFAH1B1/PPP2CB/FZD7/RHOA/FZD5/PRKCQ/PRKCB/CD44/JUN/PRKCZ/PRKCD/FZD4/LDLR/NKD2/CCND3/PRKCH/WNT3A/PRKCE/PRKD1/NKD1/AXIN2
51 WP1449 WP1449 Regulation of toll-like receptor signaling pathway 143 -0.507378430442551 -1.85054502255692 0.00253164556962025 0.0136986301369863 0.00729992790194665 5125 tags=41%, list=21%, signal=33% RAC1/CCL5/CHUK/RELA/TIRAP/SQSTM1/SYK/MAPK10/TRAF6/CCL4/OTUD5/IFNA14/RIPK1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/CISH/TRAFD1/RNF41/TLR7/MAP2K4/MAPK14/NFKB1/IL1B/TLR5/CD40/CD86/AKT1/SFTPD/MAPK9/CTNNAL1/FOS/TLR3/TNFAIP3/TOLLIP/MAP3K8/TLR2/PIK3R3/PELI3/IRF5/IL6/TREM1/PTPN6/ZMYND11/MAPK1/NFKBIA/IRAK3/PIK3R1/PIK3R5/JUN/MYD88/TLR8/SFTPA2/BTK/TLR4/SMAD6
52 WP35 WP35 G Protein Signaling Pathways 94 -0.589402590436537 -2.00316087263184 0.00253164556962025 0.0136986301369863 0.00729992790194665 2550 tags=40%, list=11%, signal=36% PRKAR2B/GNA11/AKAP11/PRKAR2A/ADCY5/PDE4B/PDE8A/PRKAR1A/AKAP4/PDE4A/AKAP7/CALM1/PDE8B/GNAI1/ITPR1/RHOA/PPP3CC/PDE1C/PRKCQ/PRKACA/PRKCB/AKAP2/AKAP13/GNGT2/RRAS/ADCY4/ADCY9/GNAI2/PRKCZ/GNG7/SLC9A1/PRKCD/PDE1B/PRKCH/PRKCE/PRKD1/GNAQ
53 WP4217 WP4217 Ebola Virus Pathway on Host 129 -0.604719341351543 -2.17244775160068 0.00253164556962025 0.0136986301369863 0.00729992790194665 4950 tags=51%, list=20%, signal=41% ITGA5/ACTB/NPC2/TIMD4/TPCN2/HLA-F/BST2/CLTB/ADAM17/CTSL/HLA-DQB1/EPS15/DDX58/ICAM3/RFC1/HLA-DOB/MAPK3/ITGA1/SOCS3/NFKB1/RAB7A/VPS18/FOLR1/TYRO3/HLA-DMB/CLEC6A/EP300/AKT1/VPS11/AXL/RAB5A/HLA-DRB5/CLEC10A/HLA-DRB1/FLNA/HAVCR2/IQGAP1/ITGA3/ACTN4/RAB9A/HLA-DRA/PIK3R3/HLA-DMA/VPS39/RHOA/GSN/HLA-DQA2/HLA-DQA1/ASGR1/HLA-DQB2/HLA-G/MAPK1/HLA-DPB1/RHOB/HLA-E/PIK3R1/DAB2IP/ICAM2/CAV3/CLEC4M/CAV2/TLR4/HLA-DPA1/HLA-DOA/CAV1
54 WP4666 WP4666 Hepatitis B infection 152 -0.478187392186986 -1.75338279172837 0.00253164556962025 0.0136986301369863 0.00729992790194665 5024 tags=38%, list=21%, signal=30% CHUK/JAK2/RELA/TIRAP/SMAD4/MAPK10/TRAF6/DDB2/MAVS/IFNA14/DDX58/MAP2K3/TAB1/RAF1/MAP2K1/TAB2/MAPK3/NFATC2/IFIH1/MAP2K4/DDX3X/MAPK14/TGFB2/YWHAB/NFKB1/EGR2/CASP10/SOS2/EP300/AKT1/MAPK9/STAT6/CDKN1A/FOS/GRB2/NFATC1/STAT5B/JAK1/ATP6AP1/ARAF/TLR3/TGFB1/TLR2/PIK3R3/STAT3/IL6/STAT5A/PRKCB/NFATC3/PTK2B/MAPK1/PIK3R1/JUN/MYD88/CASP12/TLR4/TGFBR2
55 WP2380 WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 144 -0.521528155745828 -1.89448800527984 0.00255754475703325 0.0136986301369863 0.00729992790194665 3762 tags=38%, list=15%, signal=32% RAF1/MAP2K1/MAPK3/CTNNB1/ALPL/MAPK14/CYFIP1/CAMK1/FYN/NFKB1/EGR2/APC/KCNN2/MAPK7/RHOG/EGR1/AKT1/MAP2K5/MAPK9/RPS6KA1/FOS/SHC3/GRB2/STAT5B/RAP1A/IRS1/KCNA3/KIDINS220/CDKL5/STAT3/CAMK2A/STAT5A/BMP2/PTK2B/MEF2A/NTRK3/MAPK1/NTRK2/NFKBIA/PIK3R1/JUN/ACACB/FOXO3/PRKCD/SIRPA/NCF1/BDNF/CNR1/NCF2/RASGRF1/SORT1/GRIA1/DPYSL2
56 WP2355 WP2355 Corticotropin-releasing hormone signaling pathway 93 -0.531240232360081 -1.79886540543531 0.00256410256410256 0.0136986301369863 0.00729992790194665 4685 tags=48%, list=19%, signal=39% GRK6/GSK3B/PLCG1/ACACA/CRHBP/FOSL2/POMC/RAF1/MAP2K1/GNA11/FOSB/MAPK3/TCF4/CTNNB1/MAPK14/JUNB/NFKB1/PLCG2/CRH/AKT1/ERN1/MAPK9/IL2/FOS/JUND/KRT1/GJA1/TGFB1/GNAI1/RHOA/CAMK2A/PRKCQ/RAPGEF3/PRKCB/GRK3/ARRB2/MAPK1/NFKBIA/GNAI2/PRKCD/CASP12/TLR4/ARRB1/GNAQ
57 WP306 WP306 Focal Adhesion 198 -0.518087693346908 -1.9576602945688 0.00261780104712042 0.0136986301369863 0.00729992790194665 3848 tags=37%, list=16%, signal=31% PDPK1/RAF1/MAP2K1/PDGFRA/LAMC3/MAPK3/ARHGAP35/CTNNB1/ITGA1/THBS1/FYN/ITGB6/FN1/CAPN2/PAK4/CCND2/MYL12A/ROCK1/PTEN/ROCK2/AKT1/PIP5K1C/PDGFA/PPP1R12C/MAPK9/LAMA2/CRKL/SHC3/GRB2/FLNA/PARVB/CRK/RAP1A/VAV1/ITGA3/RAC2/ACTN4/ILK/ITGA9/DIAPH1/PIK3R3/RHOA/PARVA/ZYX/PRKCB/VCL/LAMB2/KDR/RAPGEF1/ITGA10/ITGA2B/MAPK1/TLN1/PIK3R1/JUN/TNXB/MYL9/HCK/LAMA3/MYLK/CAV3/CAV2/PARVG/CCND3/VWF/PDGFB/COL4A4/VEGFD/RASGRF1/FGR/ITGA8/CAV1
58 WP481 WP481 Insulin Signaling 160 -0.558049183557073 -2.05099522607501 0.00261780104712042 0.0136986301369863 0.00729992790194665 3932 tags=38%, list=16%, signal=32% PPP1R3A/MAP2K3/PDPK1/RAF1/MAP2K1/MAPK3/FLOT2/STXBP1/MAP2K4/MAPK14/SOCS3/TBC1D4/RHOQ/MAPK7/MAP3K11/PTEN/MINK1/EGR1/SOS2/GAB1/AKT1/MAP2K5/MAPK9/RPS6KA1/SNAP23/FOS/SHC3/GRB2/SGK3/MAPK4/CRK/RAC2/IRS1/MAP4K2/STXBP2/MAP3K8/PIK3R3/PIK3C2G/PRKCQ/MAP3K6/PRKCB/RAPGEF1/MAPK1/FOXO1/EHD1/PIK3R1/JUN/PTPN1/MYO1C/VAMP2/MAP3K3/PRKCZ/FOXO3/SGK1/PRKCD/SORBS1/PRKCH/RPS6KA2/EHD2/RHOJ
59 WP706 WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 160 -0.402371045121336 -1.47883218356196 0.00261780104712042 0.0136986301369863 0.00729992790194665 3799 tags=32%, list=16%, signal=28% PPARGC1B/TAC1/PRKAR2A/YWHAH/RUNX3/CTNNB1/SLC1A3/YWHAB/NFKB1/IL1B/MECP2/EGR1/CHRNA4/EP300/SSTR1/HADHB/PRKAR1A/NR3C1/KCNQ1/SLC25A4/GJA1/HADHA/C4A/TPPP/GATA3/CPT1A/IL6/PRKACA/PBX1/IL1A/C4B/THRB/NTRK2/JUN/SPTBN1/AR/TSPYL1/VAMP2/GPD1L/KCNJ8/FMO3/CAV3/BDNF/IL6R/SCN4B/AQP4/GATA2/VIPR1/CHRM2/MAOA/SLC6A4
60 WP289 WP289 Myometrial Relaxation and Contraction Pathways 156 -0.495512547324554 -1.8138804577885 0.00263157894736842 0.0136986301369863 0.00729992790194665 3857 tags=39%, list=16%, signal=33% RGS19/CNN2/PRKAR2B/ACTA2/PRKAR2A/YWHAH/ADCY5/MYL4/RGS16/GUCY1A1/YWHAB/NFKB1/IL1B/ATF3/RGS18/PLCG2/RYR1/GNG2/CRH/CNN1/PKIA/ETS2/PDE4B/SLC8A1/RGS2/FOS/PRKAR1A/MAFF/IGFBP1/CALM1/GJA1/ITPR1/IL6/CAMK2A/PRKCQ/PRKACA/RGS6/PRKCB/PKIG/PLCD1/ARRB2/ADCY4/JUN/ADCY9/PRKCZ/GNG7/PRKCD/NOS1/RGS5/PRKCH/ARRB1/PRKCE/GUCA2A/PRKD1/GNAQ/RXFP1/RGS9/RAMP2/RAMP3/GRK5
61 WP3929 WP3929 Chemokine signaling pathway 164 -0.529961471137152 -1.95216415864642 0.00263852242744063 0.0136986301369863 0.00729992790194665 2991 tags=32%, list=12%, signal=29% ROCK1/ROCK2/GNG2/SOS2/AKT1/CXCL12/CRKL/SHC3/GRB2/CCL24/STAT5B/CRK/RAP1A/VAV1/RAC2/PF4/GNAI1/PIK3R3/CCR1/STAT3/CXCR4/CXCL16/PRKCB/GNGT2/PTK2B/DOCK2/ARRB2/MAPK1/XCR1/ADCY4/NFKBIA/PIK3R1/PIK3R5/ADCY9/GNAI2/CXCR2/HCK/PRKCZ/GNG7/WAS/FOXO3/PRKCD/NCF1/CX3CL1/RASGRP2/ELMO1/PLCB2/ARRB1/CX3CR1/PREX1/FGR/GRK5
62 WP437 WP437 EGF/EGFR Signaling Pathway 163 -0.567435392513956 -2.08919690999873 0.00263852242744063 0.0136986301369863 0.00729992790194665 4418 tags=42%, list=18%, signal=35% PIK3C2B/PLCG1/AP2M1/MAP3K4/EPS15/MAP4K1/PDPK1/RAF1/MAP2K1/FOSB/MEF2D/LIMK2/STXBP1/PTPN12/MAPK14/STAM/RALBP1/ROCK1/MAPK7/PTEN/USP8/SOS2/GAB1/AKT1/MAP2K5/RAB5A/MAPK9/RPS6KA1/INPP5D/CRKL/FOS/JUND/GRB2/STAT5B/JAK1/IQGAP1/MAPK4/CRK/RAP1A/VAV1/GJA1/IQSEC1/PTPN5/STAT3/CAMK2A/STAT5A/SH3KBP1/PRKCB/PEBP1/PTK2B/MEF2A/MAPK1/FOXO1/SH3GL3/FOXO4/PLCE1/PIK3R1/JUN/MAP3K3/PRKCZ/PRKCD/SPRY2/GAB2/CAV2/DOK2/RPS6KA2/REPS2/CAV1
63 WP4223 WP4223 Ras Signaling 184 -0.475218887563424 -1.77943506956402 0.00268096514745308 0.0136986301369863 0.00729992790194665 3925 tags=35%, list=16%, signal=30% GNG5/RAF1/MAP2K1/PDGFRA/STK4/MAPK3/PLA2G4E/PLA2G4D/ETS1/PLA2G3/SHOC2/NFKB1/RALBP1/CSF1R/PAK4/PLA1A/PLCG2/GNG2/PAK5/SOS2/RGL1/GAB1/AKT1/ETS2/RAB5A/RRAS2/BCL2L1/MAPK9/FLT4/PLA2G5/SHC3/GRB2/PLAAT3/CALM1/RAP1A/RAC2/PIK3R3/RHOA/PRKACA/PRKCB/KDR/GNGT2/PLA2G4C/RAPGEF5/RAB5B/MAPK1/RRAS/NTRK2/FGFR2/FOXO4/PLCE1/PIK3R1/GNG7/GAB2/MRAS/FGFR4/RASGRP2/RASSF5/PLA2G12B/RASGRP4/TEK/PLA2G4F/PLA2G1B/RASGRF1
64 WP3888 WP3888 VEGFA-VEGFR2 Signaling Pathway 236 -0.589062517396146 -2.26327859348876 0.00271739130434783 0.0136986301369863 0.00729992790194665 3823 tags=40%, list=16%, signal=34% CAMKK2/PDPK1/RAF1/MAP2K1/F3/ELOA/MAPK3/DOK1/ETS1/NFATC2/CTNNB1/MAP2K4/CTNNA1/MAPK14/HDAC5/STAM/OCLN/FGG/FYN/MYH9/NFKB1/FGA/CTNND1/CAPN2/ROCK1/PTPRJ/ROCK2/EGR1/SHB/FBXW11/GAB1/AKT1/RAB11A/ERN1/HBEGF/RCAN1/SLC8A1/RAB5A/HDAC7/BCL2L1/MAPK9/STAT6/PLA2G5/SOD2/GRB2/NFATC1/IQGAP1/CRK/RAP1A/GJA1/ICAM1/MKNK1/EZR/RHOA/PTPN9/ADAMTS1/STAT3/PRKCB/CCN2/VCL/PTPN6/KDR/RAPGEF1/PTK2B/ARRB2/MAPK1/FOXO1/FOXO4/NFKBIA/PIK3R1/JUN/PTPN1/PRKG1/TNXB/SMARCA2/ACACB/PRKCZ/FOXO3/PRKCD/ERG/NCF1/ARHGEF15/NOTCH4/MMRN2/PRKCE/PRKD1/RCAN2/RHOJ/TXNIP/NCF2/CDH5/KL/CAV1
65 WP382 WP382 MAPK Signaling Pathway 246 -0.489721566933744 -1.8914958861666 0.00273972602739726 0.0136986301369863 0.00729992790194665 3932 tags=36%, list=16%, signal=31% MAX/MAPKAPK3/PPP5D1/MAP2K3/TAB1/CACNG2/RAF1/MAP2K1/TNFRSF1A/STK4/TAB2/MAPK3/PLA2G4E/PLA2G4D/MAP2K4/PPM1B/MAPK14/TGFB2/CACNG4/NFKB1/IL1B/TAOK3/MAPK7/MAP3K11/CACNA1C/TAOK2/SOS2/AKT1/MAP2K5/CACNA1D/PDGFA/CACNB4/RRAS2/RAPGEF2/MAPK9/CACNA2D2/CRKL/FOS/LRRK2/JUND/GRB2/FLNA/NFATC1/FGF18/ARAF/CRK/RAP1A/RAC2/DUSP7/MAP4K2/FGF7/TGFB1/MKNK1/MAP3K8/DUSP16/IL1R1/FGF10/PTPN5/PPP3CC/PRKACA/MAP3K6/MKNK2/NFATC3/IL1A/PLA2G4C/DUSP3/ARRB2/MAPK1/RRAS/NTRK2/FGFR2/JUN/HSPA2/PRKCD/DUSP6/MRAS/FGFR4/BDNF/RASGRP2/DUSP1/RASGRP4/PLA2G4F/FGF2/CACNA1S/PDGFB/ARRB1/TGFBR2/RASGRF1
66 WP3959 WP3959 DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM 55 0.582197440322824 1.76019258020718 0.00344234079173838 0.0169469085131736 0.00903091835241487 6494 tags=45%, list=27%, signal=33% CDKN2A/CDC25C/CHEK1/EXO1/FANCD2/BRCA1/RAD51/BLM/BRCA2/CASP3/PRKDC/H2AFX/CHEK2/ACTL6A/E2F1/PCNA/ATM/MRE11/RIF1/PARP1/ATR/RAD9A/TP73/RAD52/CDK5
67 WP45 WP45 G1 to S cell cycle control 64 0.556928674132859 1.71459626479989 0.00350877192982456 0.0170122275385433 0.00906572651725006 4697 tags=48%, list=19%, signal=39% CDKN2A/POLE2/CCNB1/ORC6/MCM4/CDK1/CDC45/CCNE2/ORC1/TFDP1/MCM2/CCNE1/CDC25A/E2F2/MCM6/MYT1/PRIM2/CREB3L4/POLE/E2F3/MCM7/CDKN2C/RPA3/WEE1/PRIM1/GADD45A/E2F1/ORC2/PCNA/ATM/MCM3
68 WP3965 WP3965 Lipid Metabolism Pathway 29 -0.644170593288779 -1.7565770866349 0.00451467268623025 0.0184997832056656 0.00985843710301915 4413 tags=48%, list=18%, signal=40% PRKACB/BCKDHA/ACACA/PRKAR2B/FASN/PRKAR2A/PNPLA2/PRKAB1/AKT1/PRKAR1A/PRKACA/ACSS2/ABHD5
69 WP3972 WP3972 PDGFR-beta pathway 29 -0.703598072588881 -1.91862880017568 0.00451467268623025 0.0184997832056656 0.00985843710301915 5099 tags=59%, list=21%, signal=46% JAK2/PLCG1/RAF1/MAP2K1/MAPK3/MAP2K4/STAT6/FOS/GRB2/STAT5B/JAK1/STAT3/STAT5A/PRKCB/PIK3R1/JUN
70 WP2526 WP2526 PDGF Pathway 40 -0.612454490672276 -1.78473542851409 0.00454545454545455 0.0184997832056656 0.00985843710301915 5099 tags=52%, list=21%, signal=42% RAC1/CHUK/PLCG1/RAF1/MAP2K1/MAPK3/MAP2K4/NFKB1/PDGFA/FOS/GRB2/JAK1/VAV1/RHOA/STAT3/MAPK1/NFKBIA/PIK3R1/JUN/PDGFB
71 WP3298 WP3298 Melatonin metabolism and effects 38 -0.627506056973278 -1.81250107551413 0.00455580865603645 0.0184997832056656 0.00985843710301915 4443 tags=53%, list=18%, signal=43% TRAF6/GSK3B/MAP2/CYP1B1/CYP1A1/NFKB1/PER3/CRY1/APOE/CALM1/SULT1A1/CAMK2A/PER1/FOXO1/CRY2/CYP1A2/MAOA/EDN1/ADRB1
72 WP143 WP143 Fatty Acid Beta Oxidation 34 -0.643312671618906 -1.80765765982521 0.0045662100456621 0.0184997832056656 0.00985843710301915 3837 tags=44%, list=16%, signal=37% ACADS/ACAT1/PNPLA2/ACSL5/HADHB/ACSL4/HADHA/CPT1A/SLC25A20/DECR1/ACSS2/ACSL1/LPL/ACADL
73 WP2197 WP2197 Endothelin Pathways 34 -0.610275753893501 -1.71482653738974 0.0045662100456621 0.0184997832056656 0.00985843710301915 3731 tags=47%, list=15%, signal=40% MAP2K1/EDNRA/CNN1/NPY1R/CALM1/GNAI1/NPY/MAPK1/ADRA1A/MYLK/PTGIR/CALCRL/EDN1/ADRB1/EDNRB
74 WP313 WP313 Signaling of Hepatocyte Growth Factor Receptor 34 -0.634577940990779 -1.78311375851093 0.0045662100456621 0.0184997832056656 0.00985843710301915 4542 tags=56%, list=19%, signal=45% PXN/MAP4K1/RAF1/MAP2K1/MAPK3/ITGA1/PTEN/GAB1/CRKL/FOS/GRB2/CRK/RAP1A/STAT3/RAPGEF1/PTK2B/MAPK1/JUN
75 WP422 WP422 MAPK Cascade 33 -0.670850003116976 -1.87313043977875 0.00460829493087558 0.0184997832056656 0.00985843710301915 4622 tags=48%, list=19%, signal=39% MAP2/MAP2K3/RAF1/MAP2K1/MAPK3/MAP2K4/MAPK14/SOS2/GRB2/ARAF/MAPK1/RRAS/MBP/JUN/MAP3K3
76 WP2324 WP2324 AGE/RAGE pathway 66 -0.612892706020922 -1.97297630344254 0.00464037122969838 0.0184997832056656 0.00985843710301915 3731 tags=56%, list=15%, signal=48% CHUK/JAK2/RELA/TIRAP/SP1/INS/RAF1/MAP2K1/MAPK3/ALPL/MAPK14/NFKB1/ROCK1/AKT1/MMP7/MAPK9/STAT5B/IRS1/DIAPH1/EZR/RHOA/STAT3/STAT5A/PRKCB/MAPK1/FOXO1/FOXO4/NFKBIA/JUN/MYD88/PRKCZ/PRKCD/MSN/NCF1/MSR1/AGER
77 WP2374 WP2374 Oncostatin M Signaling Pathway 65 -0.597863939945069 -1.91873157520145 0.00465116279069767 0.0184997832056656 0.00985843710301915 3731 tags=49%, list=15%, signal=42% MAP2K1/MAPK3/MAPK14/CDKN1B/JUNB/SOCS3/NFKB1/EGR1/AKT1/LIFR/CASP7/MAPK9/FOS/JUND/GRB2/STAT5B/JAK1/IRS1/CCN1/STAT3/IL6ST/PRKCB/PTK2B/MAPK1/NFKBIA/PIK3R1/TIMP3/PRKCD/LDLR/PRKCH/PRKCE
78 WP2849 WP2849 Hematopoietic Stem Cell Differentiation 63 -0.597628338095296 -1.90855669448911 0.00465116279069767 0.0184997832056656 0.00985843710301915 3661 tags=48%, list=15%, signal=41% MXI1/GYPA/CSF1/NFATC2/IL1B/CIITA/IKZF1/NOTCH1/LYL1/FOS/ZNF835/VAV1/IRF5/IL6/CXCR4/STAT5A/CSF3/GATA1/GP9/IL1A/ITGA2B/THRB/CD34/TNXB/FLI1/LMO2/NCKAP1L/SPI1/GATA2
79 WP364 WP364 IL-6 signaling pathway 43 -0.601223554064732 -1.76855203436559 0.00468384074941452 0.0184997832056656 0.00985843710301915 3728 tags=47%, list=15%, signal=39% MAPK3/MAP2K4/JUNB/SOCS3/GAB1/AKT1/BCL2L1/GRB2/JAK1/VAV1/NCOA1/STAT3/IL6/IL6ST/MAPK1/PIK3R1/HCK/PRKCD/IL6R
80 WP3303 WP3303 RAC1/PAK1/p38/MMP2 Pathway 68 -0.568156096046623 -1.84262663906128 0.00472813238770686 0.0184997832056656 0.00985843710301915 3580 tags=38%, list=15%, signal=33% MAPK3/CTNNB1/TNIP1/MAPK14/NFKB1/FN1/ANGPTL1/AKT1/CASP7/MAPK9/GRB2/STAT5B/CRK/STAT3/STAT5A/MAPK1/FOXO1/NFKBIA/PIK3R1/NOS1/TEK/DOK2/RS1/ANGPT4/ANGPT1
81 WP1541 WP1541 Energy Metabolism 47 -0.56738906134756 -1.69977606938516 0.00476190476190476 0.0184997832056656 0.00985843710301915 5054 tags=34%, list=21%, signal=27% CAMK2G/SIRT1/GSK3B/PPARGC1B/MEF2D/MAPK14/PRKAB1/EP300/NCOA1/PPP3CC/RXRA/MEF2A/FOXO1/FOXO3/PPARG
82 WP1982 WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling 71 -0.575739856062364 -1.87499972021835 0.00488997555012225 0.0184997832056656 0.00985843710301915 4836 tags=41%, list=20%, signal=33% ACSS1/SP1/SCAP/SIRT1/ACACA/INS/FDFT1/PPARGC1B/FASN/SCD/MED15/IDI1/SREBF2/PRKAB1/NR1H2/LSS/INSIG1/AKT1/GPAM/SAR1A/CYP51A1/HMGCS1/PRKACA/HMGCR/LDLR/LPL/RBP4/PPARG
83 WP4205 WP4205 MET in type 1 papillary renal cell carcinoma 59 -0.549954819803464 -1.71011250062039 0.00488997555012225 0.0184997832056656 0.00985843710301915 4385 tags=42%, list=18%, signal=35% C8orf34/RAF1/MAP2K1/ELOA/MAPK3/ETS1/PAK4/PAK5/SOS2/GAB1/AKT1/CDKN1A/CRKL/GRB2/TFE3/ARAF/CRK/RAP1A/PIK3R3/STAT3/RAPGEF1/MAPK1/PIK3R1/JUN
84 WP4538 WP4538 Regulatory circuits of the STAT3 signaling pathway 78 -0.533002986817774 -1.76304079571372 0.00488997555012225 0.0184997832056656 0.00985843710301915 3960 tags=41%, list=16%, signal=34% CTF1/PDGFRA/CNTFR/PTPRC/MAPK3/PTPRD/MAPK14/SOCS3/MAPK7/LIFR/IL11RA/MAPK9/CSF2RB/JAK1/MAPK4/CSF3R/IL2RG/STAT3/IL6ST/PRKCB/IL10RA/AGTR2/MAPK1/GHR/IFNLR1/IL3RA/IL20RA/IL7R/IL6R/F2RL3/AGTR1
85 WP428 WP428 Wnt Signaling 115 -0.460205606485278 -1.63752085375515 0.00490196078431373 0.0184997832056656 0.00985843710301915 5162 tags=42%, list=21%, signal=33% FZD8/RAC1/PPP3CB/CAMK2G/CHD8/WNT2B/GSK3B/LRP6/CCND1/DAAM1/NOTUM/SOST/WNT2/TCF7L1/NFATC2/CTNNB1/FZD1/APC/CCND2/ROCK2/WNT7A/SFRP5/MAPK9/TCF7L2/NFATC1/FRAT1/FZD7/CTNNBIP1/RHOA/FZD5/PPP3CC/CAMK2A/ROR1/DKK2/PRKCB/NFATC3/PRICKLE1/GPC4/DAAM2/JUN/SOX17/PLCB2/NKD2/CCND3/PRICKLE2/WNT3A/NKD1
86 WP4321 WP4321 Thermogenesis 108 -0.472966706268173 -1.66119186812598 0.00491400491400491 0.0184997832056656 0.00985843710301915 3860 tags=28%, list=16%, signal=23% MAP2K3/ADRB3/ARID1A/ADCY5/SMARCD3/PNPLA2/MAPK14/PRKAB1/SOS2/ACSL5/PRDM16/RPS6KA1/GRB2/ACSL4/CPT1A/SLC25A20/KLB/PRKACA/ADCY4/ADCY9/PRKG1/SMARCA2/ACSL1/MGLL/RPS6KA2/CNR1/PPARG/PRKG2/NPR1
87 WP673 WP673 ErbB Signaling Pathway 91 -0.50746055745121 -1.71751967058708 0.005 0.0186046511627907 0.00991432068543452 4412 tags=37%, list=18%, signal=31% GSK3B/PLCG1/CCND1/RAF1/MAP2K1/MAPK3/MAP2K4/CDKN1B/PAK4/PLCG2/PAK5/SOS2/GAB1/AKT1/HBEGF/ERBB4/MAPK9/CDKN1A/CRKL/SHC3/GRB2/STAT5B/ARAF/CRK/PIK3R3/CAMK2A/STAT5A/PRKCB/MAPK1/FOXO1/PIK3R1/JUN/NRG3
88 WP26 WP26 Signal Transduction of S1P Receptor 25 -0.682006331746115 -1.78248631708789 0.00683371298405467 0.0241545893719807 0.0128718535469108 3558 tags=48%, list=15%, signal=41% S1PR2/MAPK7/AKT1/MAPK4/GNAI1/S1PR5/MAPK1/ASAH1/GNAI2/PLCB2/S1PR1
89 WP465 WP465 Tryptophan metabolism 42 -0.568462525644927 -1.66828060658117 0.00683371298405467 0.0241545893719807 0.0128718535469108 4138 tags=40%, list=17%, signal=34% ACAT1/CYP1A1/ALDH3A2/ALDH1A1/WARS/IDO1/HAAO/ALDH2/OGDH/ALDH1A2/DHCR24/AOX1/CYP1A2/CAT/MAOB/INMT
90 WP4496 WP4496 Signal transduction through IL1R 33 -0.607456486490543 -1.69612466333712 0.00691244239631336 0.0241545893719807 0.0128718535469108 5125 tags=61%, list=21%, signal=48% MAP3K14/CHUK/RELA/TRAF6/MAP2K3/TAB1/MAPK14/TGFB2/NFKB1/IL1B/TGFB1/TOLLIP/IL1R1/IL6/IL1A/NFKBIA/IRAK3/JUN/MYD88
91 WP363 WP363 Wnt Signaling Pathway 51 -0.558895422142045 -1.70696125777929 0.00696055684454756 0.0241545893719807 0.0128718535469108 3489 tags=43%, list=14%, signal=37% LRP6/CCND1/TCF4/NFATC2/CTNNB1/APC/AKT1/MAPK9/TCF7L2/FRAT1/GJA1/RHOA/ROR1/PI4K2A/PRKCB/ARRB2/MAPK1/TEK/PIP5K1B/AXIN2/PPARG
92 WP3680 WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways 66 -0.493591530412936 -1.58893128196474 0.00696055684454756 0.0241545893719807 0.0128718535469108 4412 tags=42%, list=18%, signal=35% PLCG1/DAAM1/RAF1/MAP2K1/CTNNB1/FZD1/MAP2K4/TMSB4X/CAMK1/CDKN1B/APC/FN1/ROCK2/AKT1/ERBB4/CDKN1A/GRB2/FZD7/RHOA/FZD5/STAT5A/MAPK1/JUN/MYLK/FZD4/NOS1/GRIA1
93 WP2525 WP2525 Trans-sulfuration and one carbon metabolism 31 0.619974131511702 1.66092493808102 0.00706713780918728 0.0241545893719807 0.0128718535469108 5937 tags=55%, list=24%, signal=41% DNMT3B/PSAT1/GCLC/TYMS/GCLM/MTHFD2L/CTH/PSPH/MTHFD2/BHMT/DHFR/SHMT2/DNMT3A/MAT1A/DNMT3L/CBS/DNMT1
94 WP585 WP585 Interferon type I signaling pathways 54 -0.512799005748204 -1.5738123030745 0.00707547169811321 0.0241545893719807 0.0128718535469108 3823 tags=33%, list=16%, signal=28% PTPRC/MAPK14/FYN/SOCS3/CRKL/JAK1/CRK/RAP1A/VAV1/IRS1/STAT3/STAT5A/PTPN6/RAPGEF1/PIAS1/PIK3R1/GAB2
95 WP4534 WP4534 Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms 47 -0.553002892571109 -1.65667818984855 0.00714285714285714 0.0241545893719807 0.0128718535469108 4886 tags=43%, list=20%, signal=34% ACTC1/TEAD1/TEAD4/MAPK10/TEAD3/MAP4K1/ITGB7/ACTA2/CTNNB1/CTNNA1/ITGB6/PAK4/PAK5/MAPK9/MAP4K2/ITGB2/SAV1/LIMD1/SGMS1
96 WP61 WP61 Notch Signaling Pathway 61 -0.50872642550276 -1.60237771110551 0.00717703349282297 0.0241545893719807 0.0128718535469108 5901 tags=51%, list=24%, signal=39% NCOR1/HEY2/SNW1/MAML2/PSEN2/DLL4/JAK2/NCSTN/SKP1/ADAM17/GSK3B/NCOR2/NOTCH2/CCND1/NFKB1/PSEN1/EP300/AKT1/NOTCH1/CDKN1A/GATA3/CIR1/STAT3/HEY1/NUMB/PIK3R1/APH1B/NOTCH4/PTCRA/FHL1
97 WP558 WP558 Complement and Coagulation Cascades 58 -0.517764904303038 -1.60778753824715 0.0072463768115942 0.0241545893719807 0.0128718535469108 1588 tags=34%, list=7%, signal=32% C3/C1QC/C3AR1/SERPINF2/SERPINA1/C1QA/C4B/THBD/C7/F8/C1QB/SERPIND1/SERPING1/CFD/C5AR1/VWF/MASP1/PROS1/CPB2
98 WP710 WP710 DNA Damage Response (only ATM dependent) 111 -0.421948465844916 -1.4909399130155 0.00738916256157635 0.0243642454697731 0.0129835781779712 3454 tags=32%, list=14%, signal=27% TCF7L1/CTNNB1/CDKN1B/NFKB1/APC/CCND2/PTEN/SOS2/WNT7A/AKT1/MAPK9/BCL6/PPP2R5C/CDKN1A/TCF7L2/PCK2/SOD2/GRB2/FRAT1/RAC2/IRS1/TGFB1/PIK3R3/RHOA/PIK3C2G/MAPK1/PIK3R1/PIK3R5/JUN/FOXO3/LDLR/CCND3/WNT3A/CAT
99 WP15 WP15 Selenium Micronutrient Network 89 -0.463322668064958 -1.55866650168236 0.00753768844221105 0.0243642454697731 0.0129835781779712 3493 tags=31%, list=14%, signal=27% GGTLC1/FGG/NFKB1/IL1B/ABCA1/FGA/SELENON/SERPINA3/SOD2/DIO3/ICAM1/PTGS1/IL6/KMO/ALOX15B/GGTLC2/ALOX5AP/APOA1/GGT1/LDLR/SOD3/HBB/GPX3/HBA1/CAT/ALOX5/SELENOP
100 WP2328 WP2328 Allograft Rejection 89 -0.499394293978949 -1.68001526971948 0.00753768844221105 0.0243642454697731 0.0129835781779712 3134 tags=40%, list=13%, signal=35% CD40/C2/HLA-DMB/CD86/C3/CXCL12/HLA-DRB5/CASP7/IL2/HLA-DRB1/CD40LG/LRRK2/C1QC/TGFB1/C8B/HLA-DRA/C4A/HLA-DMA/HLA-DQA2/HLA-DQA1/PECR/IL1A/C1QA/C4B/HLA-G/HLA-DPB1/C7/HLA-E/C1QB/PRKCZ/C5/PRF1/HLA-DPA1/HLA-DOA/AGTR1
101 WP75 WP75 Toll-like Receptor Signaling Pathway 103 -0.47066931532722 -1.62692638985206 0.00775193798449612 0.0248062015503876 0.013219094247246 5196 tags=42%, list=21%, signal=33% TNF/RAC1/CCL5/CHUK/RELA/TIRAP/MAPK10/TRAF6/CCL4/IFNA14/RIPK1/MAP2K3/TAB1/MAP2K1/TAB2/MAPK3/TLR7/MAP2K4/MAPK14/NFKB1/IL1B/TLR5/CD40/CD86/AKT1/MAPK9/FOS/TLR3/TOLLIP/MAP3K8/TLR2/PIK3R3/IRF5/IL6/MAPK1/NFKBIA/PIK3R1/PIK3R5/JUN/MYD88/TLR8/TLR4
102 WP3858 WP3858 Toll-like Receptor Signaling 31 -0.593909181131908 -1.64129979980801 0.00917431192660551 0.0286225402504472 0.0152528010545146 5024 tags=45%, list=21%, signal=36% RELA/TIRAP/TRAF6/TLR7/NFKB1/TLR5/TLR3/TOLLIP/TLR2/MAPK1/MYD88/TLR8/TLR4
103 WP244 WP244 Alpha 6 Beta 4 signaling pathway 33 -0.592696115235935 -1.65491112741854 0.00921658986175115 0.0286225402504472 0.0152528010545146 3558 tags=39%, list=15%, signal=34% MAPK14/GAB1/AKT1/LAMA2/GRB2/IRS1/RHOA/LAMB2/MAPK1/PIK3R1/LAMA3/PRKCD
104 WP2112 WP2112 IL17 signaling pathway 32 -0.600847580208362 -1.67140725664644 0.0092378752886836 0.0286225402504472 0.0152528010545146 5196 tags=66%, list=21%, signal=52% IL17B/MAP3K14/JAK2/RELA/IL17RB/SP1/TRAF6/GSK3B/CEBPB/IL17RE/MAPK3/NFKB1/TRAF3IP2/AKT1/JAK1/STAT3/MAPK1/CEBPD/IL17RA/IL17D
105 WP410 WP410 Exercise-induced Circadian Regulation 48 -0.541562832478487 -1.63667859285653 0.00930232558139535 0.0286225402504472 0.0152528010545146 3570 tags=46%, list=15%, signal=39% ARNTL/EIF4G2/CEBPB/TAB2/IDI1/TOB1/GSTM3/CRY1/GFRA1/BTG1/DAZAP2/PPP2CB/QKI/HLA-DMA/RBPMS/PER1/NCOA4/CRY2/PPP1R3C/CLDN5/KLF9
106 WP2118 WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy 74 -0.477962319992754 -1.57337705473479 0.00952380952380952 0.0290249433106576 0.0154672395273899 3848 tags=42%, list=16%, signal=35% CACNG2/TCF7L1/CTNNA3/CTNNB1/ITGA1/CTNNA1/CACNG4/ITGB6/CACNA1C/CACNA1D/CACNB4/SLC8A1/DAG1/SGCB/LAMA2/CACNA2D2/TCF7L2/SGCD/DMD/ITGA3/ACTN4/GJA1/ITGA9/ITGA10/ITGA2B/ACTN2/CACNA1S/SGCA/SGCG/ITGA8
107 WP2261 WP2261 Signaling Pathways in Glioblastoma 82 -0.46980885475768 -1.56855575596006 0.00995024875621891 0.0300384868112269 0.0160073515244038 3823 tags=40%, list=16%, signal=34% PDPK1/RAF1/MAP2K1/PDGFRA/MAPK3/MAP2K4/CDKN1B/CCND2/PTEN/PLCG2/EP300/GAB1/AKT1/MAP2K5/CDKN1A/GRB2/ARAF/IRS1/PIK3C2G/PRKCQ/PRKCB/MAPK1/FOXO1/FGFR2/FOXO4/PIK3R1/PRKCZ/FOXO3/PRKCD/SPRY2/PRKCH/CDKN2B
108 WP4263 WP4263 Pancreatic adenocarcinoma pathway 89 -0.448736434831178 -1.50959686901757 0.0100502512562814 0.0300568261870098 0.0160171244812355 3731 tags=39%, list=15%, signal=33% RAC1/CHUK/RELA/SMAD4/MAPK10/DDB2/CCND1/RAF1/MAP2K1/MAPK3/TGFB2/NFKB1/RALBP1/PAK4/PAK5/AKT1/BCL2L1/MAPK9/CDKN1A/JAK1/ARAF/RAC2/TGFB1/PIK3R3/RHOA/STAT3/PEBP1/MAPK1/PIK3R1/PRKCD/DUSP6/ARHGEF6/GADD45B/TGFBR2
109 WP1433 WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway 41 -0.540170731284649 -1.57711241728712 0.0114678899082569 0.033822348116518 0.0180237512989339 5235 tags=46%, list=22%, signal=36% CARD8/RAC1/CHUK/RELA/NLRP12/NLRP3/NOD2/PYCARD/IL1B/CASP5/CASP7/CARD9/MEFV/CASP1/NOD1/NFKBIA/CARD6/NLRC4
110 WP3676 WP3676 BDNF-TrkB Signaling 33 -0.57433990094298 -1.60365736936312 0.0115207373271889 0.033822348116518 0.0180237512989339 2738 tags=42%, list=11%, signal=38% TRPC3/MAP2K1/GAB1/AKT1/RPS6KA1/GRB2/MKNK1/MAPK1/NTRK2/GAB2/BDNF/ARC/TRPC6
111 WP4396 WP4396 Nonalcoholic fatty liver disease 155 -0.362936694457218 -1.32971578290757 0.0129533678756477 0.0376825247291569 0.0200808190990902 3164 tags=15%, list=13%, signal=14% NFKB1/IL1B/PRKAB1/MAP3K11/AKT1/ERN1/CASP7/MAPK9/IRS1/TGFB1/PIK3R3/COX7A1/IL6/RXRA/IL1A/ADIPOR2/PIK3R1/JUN/SMAD7/CEBPA/IL6R/COX4I2/LEPR
112 WP167 WP167 Eicosanoid Synthesis 26 -0.634788780537419 -1.6851790590273 0.0136363636363636 0.0387174833635814 0.0206323431082243 3378 tags=46%, list=14%, signal=40% PTGIS/PLA2G5/PTGS1/ALOX15B/GGTLC2/ALOX5AP/GGT1/LTA4H/TBXAS1/PTGDS/ALOX5
113 WP205 WP205 IL-7 Signaling Pathway 25 -0.647064231955439 -1.69116192335721 0.0136674259681093 0.0387174833635814 0.0206323431082243 4412 tags=68%, list=18%, signal=56% CCND1/MAP2K1/MAPK3/CDKN1B/FYN/AKT1/BCL2L1/STAT5B/JAK1/IL2RG/STAT3/STAT5A/PTK2B/MAPK1/PIK3R1/IL7R
114 WP2586 WP2586 Aryl Hydrocarbon Receptor 45 -0.518898697111699 -1.54927455814743 0.0137931034482759 0.0387174833635814 0.0206323431082243 4322 tags=40%, list=18%, signal=33% CYP1B1/CYP1A1/RAF1/MAP2K1/NFE2L2/CDKN1B/NFKB1/EP300/CDKN1A/ARNT/HPGDS/MAPK1/PLAGL1/LPL/KLF6/CYP1A2/CD36
115 WP268 WP268 Notch Signaling 45 -0.517665468318334 -1.54559250998549 0.0137931034482759 0.0387174833635814 0.0206323431082243 2384 tags=24%, list=10%, signal=22% NOTCH1/DTX4/NUMB/APH1B/INPP5K/KAT2B/NOTCH4/PTCRA/MFNG/KCNJ5
116 WP3863 WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 62 -0.472479499049397 -1.4986947424136 0.013986013986014 0.0389176041349954 0.0207389864140436 5125 tags=48%, list=21%, signal=38% MAP3K14/CHUK/CD8A/GSK3B/PLCG1/ICOS/RAF1/MAP2K1/PTPRC/MAPK3/LCP2/NFATC2/FYN/NFKB1/CHP1/AKT1/MAPK9/IL2/FOS/CD40LG/GRB2/CALM1/MAP3K8/PRKCQ/PTPN6/RRAS/NFKBIA/JUN/CD4
117 WP24 WP24 Peptide GPCRs 75 -0.45329305494355 -1.49817386341742 0.014218009478673 0.0392220951135807 0.0209012480539476 3865 tags=35%, list=16%, signal=29% NPY4R/HCRTR2/EDNRA/ATP8A1/GALR1/FPR3/SSTR1/NPY1R/GHSR/ACKR1/C3AR1/CCR1/CXCR4/CXCR1/AGTR2/AVPR2/CXCR2/TACR3/C5AR1/FPR1/SSTR4/FPR2/CX3CR1/AGTR1/EDNRB
118 WP176 WP176 Folate Metabolism 70 -0.464337196191892 -1.50408010089958 0.0146699266503667 0.0401228763086954 0.0213812696118706 3592 tags=37%, list=15%, signal=32% INS/MTHFS/CSF1/FOLR3/FGG/NFKB1/IL1B/ABCA1/FGA/FOLR1/FOLR2/IL2/SERPINA3/SOD2/SLC19A1/ICAM1/IL6/APOA1/LDLR/NOS1/SOD3/HBB/GPX3/HBA1/CAT
119 WP2858 WP2858 Ectoderm Differentiation 141 -0.369997509624108 -1.34987838598429 0.0151133501259446 0.040985356273748 0.0218408806458789 3453 tags=27%, list=14%, signal=23% CTNNB1/ARHGEF9/BCAS3/SNCA/GAS2L1/FYN/PI4KA/MECP2/CDON/SERPINB6/ABCC4/GLB1/ZBTB16/NFATC1/CDH6/DMD/ZNF219/BMP4/TSC22D1/PGM1/EDA/PLXNA2/NR2F2/FZD5/PLCXD3/BMPR1A/SOCS2/RAB8B/FGFR2/PTPRB/PTPN13/FZD4/SPRY2/CTNND2/SDCBP/GATA6/LDB2
120 WP1528 WP1528 Physiological and Pathological Hypertrophy of the Heart 25 -0.634959122979062 -1.6595241069428 0.0159453302961276 0.0427046263345196 0.0227570706124742 3906 tags=56%, list=16%, signal=47% MAP2K3/MAPK14/LIFR/FOS/CALM1/RHOA/STAT3/IL6ST/PRKCB/MAPK1/JUN/PRKCE/EDN1
121 WP2516 WP2516 ATM Signaling Pathway 40 0.554957330191489 1.55676315483946 0.0160142348754448 0.0427046263345196 0.0227570706124742 4611 tags=42%, list=19%, signal=34% CDC25C/CCNB1/CHEK1/CDK1/FANCD2/BRCA1/RAD51/CCNE1/CDC25A/MDM4/H2AFX/CHEK2/PIDD1/AP3B2/GADD45A/ATM/MRE11
122 WP4216 WP4216 Chromosomal and microsatellite instability in colorectal cancer 73 -0.454120807285491 -1.48751379329662 0.0169491525423729 0.0448242050707382 0.0238865829653276 4776 tags=42%, list=20%, signal=34% RAC1/SMAD4/MAPK10/GSK3B/DDB2/CCND1/RAF1/MAP2K1/MLH1/MAPK3/TCF7L1/CTNNB1/TGFB2/APC/AKT1/MAPK9/APPL1/CDKN1A/TCF7L2/FOS/ARAF/RAC2/TGFB1/RHOA/MAPK1/JUN/DCC/GADD45B/AXIN2/TGFBR2
123 WP2036 WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway 42 -0.514025556221922 -1.50852312693655 0.0182232346241458 0.0473512873631252 0.0252332518185075 5196 tags=55%, list=21%, signal=43% TNF/RAC1/CCL5/MAP3K14/CHUK/RELA/GSK3B/TRIM63/RIPK1/RAF1/MAPK3/CTNNB1/MAPK14/NFKB1/AKT1/CASP7/MAPK9/IL6/TNFSF12/MAPK1/NFKBIA/JUN
124 WP3594 WP3594 Circadian rhythm related genes 200 -0.350218594169658 -1.32383047067144 0.0182767624020888 0.0473512873631252 0.0252332518185075 3897 tags=26%, list=16%, signal=22% OPRL1/DYRK1A/ADORA2A/ID2/GNA11/HCRTR2/NAGLU/NKX2-1/RORB/PER3/PML/PTEN/CST3/ROCK2/EGR1/FBXW11/CRH/EP300/BTBD9/CRY1/KLF10/MAPK9/ID3/OPN3/JUND/NFIL3/UBC/HNF1B/ARNT/FBXL3/CPT1A/CARTPT/IL6/ARNT2/SFTPC/NTRK3/AGRP/CHRM1/PER1/SIK1/JUN/HEBP1/CRY2/PRF1/BHLHE41/GNAQ/PTGDS/PPARG/ID4/KLF9/PRKG2/SLC6A4
125 WP430 WP430 Statin Pathway 31 -0.557914902741278 -1.54182768556289 0.018348623853211 0.0473512873631252 0.0252332518185075 3115 tags=39%, list=13%, signal=34% ABCA1/APOA5/CYP7A1/APOE/CETP/HMGCR/LRP1/APOC1/APOA1/LDLR/LPL
126 WP4535 WP4535 Envelope proteins and their potential roles in EDMD physiopathology 46 -0.505460594276532 -1.5219902451176 0.0186046511627907 0.0476279069767442 0.0253806609547124 5515 tags=43%, list=23%, signal=34% PLEC/SRF/ADCY3/SMAD4/ADCY8/MAP2K1/MAPK3/ADCY5/TGFB2/TMEM43/SOS2/GRB2/TGFB1/RHOA/CCN2/MAPK1/ADCY4/SYNE3/ADCY9

16
intermediate-pathway-scripting/lung-wp-up.csv Normal file
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"","ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"
"WP2361","WP2361","Gastric Cancer Network 1","9/143","29/6577",5.83917093208771e-09,1.16783418641754e-06,1.10022273351969e-06,"TPX2/MYBL2/MCM4/ECT2/CENPF/TOP2A/KIF15/E2F7/UBE2C",9
"WP2446","WP2446","Retinoblastoma Gene in Cancer","13/143","87/6577",3.61945589920083e-08,3.61945589920083e-06,3.40990845240499e-06,"ANLN/KIF4A/POLE2/MCM4/TTK/TOP2A/CCNB1/PLK4/CCNA2/CHEK1/CCNB2/CDK1/RRM2",13
"WP179","WP179","Cell Cycle","14/143","120/6577",2.5930798178985e-07,1.728719878599e-05,1.62863609615379e-05,"ORC6/CDC6/MCM4/TTK/CDC20/CCNB1/CCNA2/CDKN2A/CHEK1/CCNB2/CDC25C/PLK1/BUB1/CDK1",14
"WP4240","WP4240","Regulation of sister chromatid separation at the metaphase-anaphase transition","5/143","15/6577",1.14163979383831e-05,0.000570819896919155,0.000537772429202783,"CDC20/CENPE/BUB1B/MAD2L1/BUB1",5
"WP4016","WP4016","DNA IR-damage and cellular response via ATR","8/143","80/6577",0.000317595396552115,0.0127038158620846,0.0119683317858587,"FOXM1/BRIP1/FANCI/CHEK1/CDC25C/PLK1/CDK1/EXO1",8
"WP4290","WP4290","Metabolic reprogramming in colon cancer","5/143","42/6577",0.00201688097946267,0.0576251708417904,0.0542889767404236,"SLC2A1/PAICS/PPAT/PSAT1/PYCR1",5
"WP466","WP466","DNA Replication","5/143","42/6577",0.00201688097946267,0.0576251708417904,0.0542889767404236,"MCM10/ORC6/CDC6/POLE2/MCM4",5
"WP45","WP45","G1 to S cell cycle control","6/143","64/6577",0.00252923418219232,0.063230854554808,0.059570120870056,"ORC6/POLE2/MCM4/CCNB1/CDKN2A/CDK1",6
"WP707","WP707","DNA Damage Response","6/143","68/6577",0.00343979431646792,0.0764398736992871,0.0720144073272232,"CCNB1/PMAIP1/CHEK1/CCNB2/CDC25C/CDK1",6
"WP2363","WP2363","Gastric Cancer Network 2","4/143","32/6577",0.00480106907376021,0.0960213814752042,0.0904622488634818,"UBE2T/TOP2A/FANCI/UBE2C",4
"WP2064","WP2064","Neural Crest Differentiation","7/143","101/6577",0.00622183455264663,0.107729465362868,0.101492496315544,"PAX7/DLL3/LHX2/TWIST1/TFAP2A/DMBX1/LHX1",7
"WP3967","WP3967","miR-509-3p alteration of YAP1/ECM axis","3/143","18/6577",0.00646376792177207,0.107729465362868,0.101492496315544,"TWIST1/COL3A1/THBS2",3
"WP2516","WP2516","ATM Signaling Pathway","4/143","40/6577",0.0106743008375553,0.15266809554818,0.143829416332233,"CCNB1/CHEK1/CDC25C/CDK1",4
"WP1530","WP1530","miRNA Regulation of DNA Damage Response","6/143","86/6577",0.0107554278231381,0.15266809554818,0.143829416332233,"CCNB1/PMAIP1/CHEK1/CCNB2/CDC25C/CDK1",6
"WP4224","WP4224","Purine metabolism","3/143","22/6577",0.0114501071661135,0.15266809554818,0.143829416332233,"PAICS/PPAT/XDH",3
1 ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
2 WP2361 WP2361 Gastric Cancer Network 1 9/143 29/6577 5.83917093208771e-09 1.16783418641754e-06 1.10022273351969e-06 TPX2/MYBL2/MCM4/ECT2/CENPF/TOP2A/KIF15/E2F7/UBE2C 9
3 WP2446 WP2446 Retinoblastoma Gene in Cancer 13/143 87/6577 3.61945589920083e-08 3.61945589920083e-06 3.40990845240499e-06 ANLN/KIF4A/POLE2/MCM4/TTK/TOP2A/CCNB1/PLK4/CCNA2/CHEK1/CCNB2/CDK1/RRM2 13
4 WP179 WP179 Cell Cycle 14/143 120/6577 2.5930798178985e-07 1.728719878599e-05 1.62863609615379e-05 ORC6/CDC6/MCM4/TTK/CDC20/CCNB1/CCNA2/CDKN2A/CHEK1/CCNB2/CDC25C/PLK1/BUB1/CDK1 14
5 WP4240 WP4240 Regulation of sister chromatid separation at the metaphase-anaphase transition 5/143 15/6577 1.14163979383831e-05 0.000570819896919155 0.000537772429202783 CDC20/CENPE/BUB1B/MAD2L1/BUB1 5
6 WP4016 WP4016 DNA IR-damage and cellular response via ATR 8/143 80/6577 0.000317595396552115 0.0127038158620846 0.0119683317858587 FOXM1/BRIP1/FANCI/CHEK1/CDC25C/PLK1/CDK1/EXO1 8
7 WP4290 WP4290 Metabolic reprogramming in colon cancer 5/143 42/6577 0.00201688097946267 0.0576251708417904 0.0542889767404236 SLC2A1/PAICS/PPAT/PSAT1/PYCR1 5
8 WP466 WP466 DNA Replication 5/143 42/6577 0.00201688097946267 0.0576251708417904 0.0542889767404236 MCM10/ORC6/CDC6/POLE2/MCM4 5
9 WP45 WP45 G1 to S cell cycle control 6/143 64/6577 0.00252923418219232 0.063230854554808 0.059570120870056 ORC6/POLE2/MCM4/CCNB1/CDKN2A/CDK1 6
10 WP707 WP707 DNA Damage Response 6/143 68/6577 0.00343979431646792 0.0764398736992871 0.0720144073272232 CCNB1/PMAIP1/CHEK1/CCNB2/CDC25C/CDK1 6
11 WP2363 WP2363 Gastric Cancer Network 2 4/143 32/6577 0.00480106907376021 0.0960213814752042 0.0904622488634818 UBE2T/TOP2A/FANCI/UBE2C 4
12 WP2064 WP2064 Neural Crest Differentiation 7/143 101/6577 0.00622183455264663 0.107729465362868 0.101492496315544 PAX7/DLL3/LHX2/TWIST1/TFAP2A/DMBX1/LHX1 7
13 WP3967 WP3967 miR-509-3p alteration of YAP1/ECM axis 3/143 18/6577 0.00646376792177207 0.107729465362868 0.101492496315544 TWIST1/COL3A1/THBS2 3
14 WP2516 WP2516 ATM Signaling Pathway 4/143 40/6577 0.0106743008375553 0.15266809554818 0.143829416332233 CCNB1/CHEK1/CDC25C/CDK1 4
15 WP1530 WP1530 miRNA Regulation of DNA Damage Response 6/143 86/6577 0.0107554278231381 0.15266809554818 0.143829416332233 CCNB1/PMAIP1/CHEK1/CCNB2/CDC25C/CDK1 6
16 WP4224 WP4224 Purine metabolism 3/143 22/6577 0.0114501071661135 0.15266809554818 0.143829416332233 PAICS/PPAT/XDH 3

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"","x"
"1","YBX2"
"2","DLX6"
"3","CELSR3"
"4","PAX7"
"5","SYT7"
"6","ANLN"
"7","GABRA3"
"8","ABCC2"
"9","DEPDC1"
"10","INSRR"
"11","ARNTL2"
"12","HMGB3"
"13","DEPDC1B"
"14","ZIC2"
"15","MAGEC2"
"16","POLQ"
"17","STYK1"
"18","COL11A1"
"19","SPAG4"
"20","VMP1"
"21","MCM10"
"22","ASPM"
"23","PHKA1"
"24","TRIP13"
"25","HMMR"
"26","PPP2R2C"
"27","KCNQ2"
"28","SPAG5"
"29","UBE2T"
"30","FAP"
"31","RBFOX1"
"32","PTPRH"
"33","NDC80"
"34","NKAIN1"
"35","IGSF9"
"36","RAD54L"
"37","TMPRSS11E"
"38","PTHLH"
"39","DNMT3B"
"40","TPX2"
"41","FER1L4"
"42","BIRC5"
"43","KIF4A"
"44","DLL3"
"45","ORC6"
"46","RGS17"
"47","CDC6"
"48","MMP11"
"49","COCH"
"50","POLE2"
"51","GINS1"
"52","MYBL2"
"53","PABPC1L"
"54","SALL4"
"55","EEF1A2"
"56","FERMT1"
"57","FAM83D"
"58","SRPX2"
"59","CENPI"
"60","RHBDL1"
"61","SALL1"
"62","OIP5"
"63","MCM4"
"64","FSD1"
"65","MAST1"
"66","STX1A"
"67","EZH2"
"68","LHX2"
"69","CA9"
"70","EBF3"
"71","DNAJC12"
"72","GALNT7"
"73","NEIL3"
"74","NCAPG"
"75","KIAA1549L"
"76","FOXM1"
"77","PRR4"
"78","CDCA3"
"79","TTK"
"80","POLR3G"
"81","ECT2"
"82","CENPA"
"83","FHL2"
"84","ABCB6"
"85","RALGPS2"
"86","AGMAT"
"87","SLC2A1"
"88","CDC20"
"89","NEK2"
"90","CENPF"
"91","KIF14"
"92","ATP10B"
"93","ONECUT2"
"94","HELLS"
"95","TMEM156"
"96","PAEP"
"97","TWIST1"
"98","CENPK"
"99","STIL"
"100","HJURP"
"101","COL10A1"
"102","WFDC3"
"103","OR2B6"
"104","C1orf61"
"105","DLGAP5"
"106","SYNGR3"
"107","VIL1"
"108","GNGT1"
"109","PAICS"
"110","PPAT"
"111","ADM2"
"112","BAIAP2L2"
"113","VGF"
"114","E2F8"
"115","EGLN3"
"116","SGO1"
"117","FAM155B"
"118","GINS2"
"119","BARX1"
"120","CA6"
"121","TOP2A"
"122","RHBG"
"123","KHDC4"
"124","FCRL2"
"125","C1QTNF6"
"126","CCNB1"
"127","CDCA8"
"128","TCN1"
"129","ACRV1"
"130","GOLM1"
"131","PSAT1"
"132","TROAP"
"133","B4GALNT1"
"134","IGF2BP3"
"135","BRIP1"
"136","ARHGEF39"
"137","TFAP2A"
"138","SLCO5A1"
"139","SULF1"
"140","KIF23"
"141","KNL1"
"142","ITPKA"
"143","BCL2L10"
"144","CGREF1"
"145","KIF11"
"146","CEP55"
"147","GPR87"
"148","ADAMTS14"
"149","DNA2"
"150","CILP"
"151","CENPE"
"152","GCNT3"
"153","PIF1"
"154","FANCI"
"155","PMAIP1"
"156","PLPP2"
"157","SLC2A5"
"158","PLK4"
"159","KIF2C"
"160","NUF2"
"161","FCRL5"
"162","CRABP2"
"163","KCNH1"
"164","HHIPL2"
"165","CDCA7"
"166","DLX1"
"167","CCDC150"
"168","ABCA12"
"169","TRPM8"
"170","OCIAD2"
"171","CCNA2"
"172","LGSN"
"173","TPBG"
"174","ZC3HAV1L"
"175","FAM83A"
"176","CDKN2A"
"177","MKI67"
"178","ADAM12"
"179","CHEK1"
"180","HMGA2"
"181","SLC7A11"
"182","CENPU"
"183","PDK1"
"184","SPOCK1"
"185","CABYR"
"186","EME1"
"187","EPHB1"
"188","MAGEC1"
"189","SLC24A2"
"190","CXCL13"
"191","GLYATL2"
"192","FBXO32"
"193","BUB1B"
"194","TMEM171"
"195","LRP8"
"196","CCNB2"
"197","DPYSL5"
"198","XDH"
"199","HIST1H2BD"
"200","CDC25C"
"201","HIST1H4H"
"202","DONSON"
"203","CILP2"
"204","TFF1"
"205","RECQL4"
"206","SPC24"
"207","TEDC2"
"208","AK4"
"209","AKR7A3"
"210","FLVCR1"
"211","KIF26B"
"212","LINC01116"
"213","TRIM46"
"214","TSACC"
"215","CRYBA2"
"216","AIM2"
"217","KIF15"
"218","MAD2L1"
"219","SFXN1"
"220","IL31RA"
"221","STEAP1"
"222","SP8"
"223","CTHRC1"
"224","MELK"
"225","TSHR"
"226","PGM2L1"
"227","SLC16A9"
"228","GJB2"
"229","SKA3"
"230","E2F7"
"231","TAF1D"
"232","GLB1L3"
"233","GPT2"
"234","PPP1R14D"
"235","NETO1"
"236","HTR3A"
"237","PLK1"
"238","GREM1"
"239","TTYH1"
"240","KLK6"
"241","RAB26"
"242","PBK"
"243","COL3A1"
"244","GDNF"
"245","SOX14"
"246","RAB3B"
"247","COL22A1"
"248","CKAP2L"
"249","BUB1"
"250","ONECUT1"
"251","CDK1"
"252","CST1"
"253","HOXB9"
"254","HS6ST2"
"255","P2RY6"
"256","RRM2"
"257","FRMD5"
"258","MTBP"
"259","C5orf34"
"260","FUT9"
"261","MYEOV"
"262","SYT12"
"263","C11orf86"
"264","MUC13"
"265","SPTBN2"
"266","NWD2"
"267","EXO1"
"268","ANKRD36C"
"269","IL20RB"
"270","LEP"
"271","UBE2C"
"272","MARCKSL1"
"273","ANKS4B"
"274","RMI2"
"275","ETV4"
"276","FAM172BP"
"277","GPX2"
"278","ATAD5"
"279","FUT2"
"280","CD19"
"281","DNAJC22"
"282","CPNE7"
"283","ANKRD18A"
"284","EMC3-AS1"
"285","NQO1"
"286","B4GALNT4"
"287","GALNT9"
"288","PYCR1"
"289","EPHA10"
"290","IQGAP3"
"291","KNTC1"
"292","POU3F2"
"293","CDCA2"
"294","PARPBP"
"295","PRAME"
"296","DNAH14"
"297","KIF18B"
"298","SAPCD2"
"299","THBS2"
"300","HPDL"
"301","ERCC6L"
"302","TNFRSF18"
"303","TMPRSS11A"
"304","BAGE2"
"305","HIST1H1C"
"306","ENTPD8"
"307","ATP2A1"
"308","XRCC2"
"309","HIST1H2AI"
"310","S100A2"
"311","HIST1H2AG"
"312","HIST1H2AD"
"313","SCN8A"
"314","HIST1H4C"
"315","DMBX1"
"316","PRB3"
"317","AKR1B10"
"318","EPS8L3"
"319","ARHGAP11A"
"320","SNORA73B"
"321","SNORA23"
"322","ZYG11A"
"323","LINC01270"
"324","IGFL2"
"325","FAM83A-AS1"
"326","LGR4"
"327","AKR7L"
"328","IGHG4"
"329","IGHG1"
"330","PPP1R14BP2"
"331","GPC2"
"332","LINC02418"
"333","VAC14-AS1"
"334","UBE2QL1"
"335","TNFRSF25"
"336","LINC01983"
"337","HAGLROS"
"338","PSMD10P2"
"339","AKR1B15"
"340","LINC02474"
"341","NKX1-2"
"342","ANKRD36BP2"
"343","FEZF1-AS1"
"344","FOXD3-AS1"
"345","DLX6-AS1"
"346","LINC00665"
"347","LINC01271"
"348","LINC02535"
"349","DSCAM-AS1"
"350","RPSAP52"
"351","SNHG3"
"352","CCDC169"
"353","MNX1-AS1"
"354","RPL18P13"
"355","LINC00461"
"356","LINC02014"
"357","LUCAT1"
"358","LINC02362"
"359","LINC01234"
"360","LINC00942"
"361","PVT1"
"362","SCARNA13"
"363","BBOX1-AS1"
"364","MEX3A"
"365","SNHG1"
"366","LINC00346"
"367","SALL3"
"368","POLG2"
"369","TUBB3"
"370","LINC02544"
"371","VPS9D1-AS1"
"372","LINC01977"
"373","RUNDC3A-AS1"
"374","AFAP1-AS1"
"375","LHX1"
"376","UHRF1"
"377","HIST1H2BF"
"378","NEFL"
"379","RDM1"
"380","HIST1H2AM"
"381","LINC01395"
"382","HELLPAR"
"383","SNHG4"
1 x
2 1 YBX2
3 2 DLX6
4 3 CELSR3
5 4 PAX7
6 5 SYT7
7 6 ANLN
8 7 GABRA3
9 8 ABCC2
10 9 DEPDC1
11 10 INSRR
12 11 ARNTL2
13 12 HMGB3
14 13 DEPDC1B
15 14 ZIC2
16 15 MAGEC2
17 16 POLQ
18 17 STYK1
19 18 COL11A1
20 19 SPAG4
21 20 VMP1
22 21 MCM10
23 22 ASPM
24 23 PHKA1
25 24 TRIP13
26 25 HMMR
27 26 PPP2R2C
28 27 KCNQ2
29 28 SPAG5
30 29 UBE2T
31 30 FAP
32 31 RBFOX1
33 32 PTPRH
34 33 NDC80
35 34 NKAIN1
36 35 IGSF9
37 36 RAD54L
38 37 TMPRSS11E
39 38 PTHLH
40 39 DNMT3B
41 40 TPX2
42 41 FER1L4
43 42 BIRC5
44 43 KIF4A
45 44 DLL3
46 45 ORC6
47 46 RGS17
48 47 CDC6
49 48 MMP11
50 49 COCH
51 50 POLE2
52 51 GINS1
53 52 MYBL2
54 53 PABPC1L
55 54 SALL4
56 55 EEF1A2
57 56 FERMT1
58 57 FAM83D
59 58 SRPX2
60 59 CENPI
61 60 RHBDL1
62 61 SALL1
63 62 OIP5
64 63 MCM4
65 64 FSD1
66 65 MAST1
67 66 STX1A
68 67 EZH2
69 68 LHX2
70 69 CA9
71 70 EBF3
72 71 DNAJC12
73 72 GALNT7
74 73 NEIL3
75 74 NCAPG
76 75 KIAA1549L
77 76 FOXM1
78 77 PRR4
79 78 CDCA3
80 79 TTK
81 80 POLR3G
82 81 ECT2
83 82 CENPA
84 83 FHL2
85 84 ABCB6
86 85 RALGPS2
87 86 AGMAT
88 87 SLC2A1
89 88 CDC20
90 89 NEK2
91 90 CENPF
92 91 KIF14
93 92 ATP10B
94 93 ONECUT2
95 94 HELLS
96 95 TMEM156
97 96 PAEP
98 97 TWIST1
99 98 CENPK
100 99 STIL
101 100 HJURP
102 101 COL10A1
103 102 WFDC3
104 103 OR2B6
105 104 C1orf61
106 105 DLGAP5
107 106 SYNGR3
108 107 VIL1
109 108 GNGT1
110 109 PAICS
111 110 PPAT
112 111 ADM2
113 112 BAIAP2L2
114 113 VGF
115 114 E2F8
116 115 EGLN3
117 116 SGO1
118 117 FAM155B
119 118 GINS2
120 119 BARX1
121 120 CA6
122 121 TOP2A
123 122 RHBG
124 123 KHDC4
125 124 FCRL2
126 125 C1QTNF6
127 126 CCNB1
128 127 CDCA8
129 128 TCN1
130 129 ACRV1
131 130 GOLM1
132 131 PSAT1
133 132 TROAP
134 133 B4GALNT1
135 134 IGF2BP3
136 135 BRIP1
137 136 ARHGEF39
138 137 TFAP2A
139 138 SLCO5A1
140 139 SULF1
141 140 KIF23
142 141 KNL1
143 142 ITPKA
144 143 BCL2L10
145 144 CGREF1
146 145 KIF11
147 146 CEP55
148 147 GPR87
149 148 ADAMTS14
150 149 DNA2
151 150 CILP
152 151 CENPE
153 152 GCNT3
154 153 PIF1
155 154 FANCI
156 155 PMAIP1
157 156 PLPP2
158 157 SLC2A5
159 158 PLK4
160 159 KIF2C
161 160 NUF2
162 161 FCRL5
163 162 CRABP2
164 163 KCNH1
165 164 HHIPL2
166 165 CDCA7
167 166 DLX1
168 167 CCDC150
169 168 ABCA12
170 169 TRPM8
171 170 OCIAD2
172 171 CCNA2
173 172 LGSN
174 173 TPBG
175 174 ZC3HAV1L
176 175 FAM83A
177 176 CDKN2A
178 177 MKI67
179 178 ADAM12
180 179 CHEK1
181 180 HMGA2
182 181 SLC7A11
183 182 CENPU
184 183 PDK1
185 184 SPOCK1
186 185 CABYR
187 186 EME1
188 187 EPHB1
189 188 MAGEC1
190 189 SLC24A2
191 190 CXCL13
192 191 GLYATL2
193 192 FBXO32
194 193 BUB1B
195 194 TMEM171
196 195 LRP8
197 196 CCNB2
198 197 DPYSL5
199 198 XDH
200 199 HIST1H2BD
201 200 CDC25C
202 201 HIST1H4H
203 202 DONSON
204 203 CILP2
205 204 TFF1
206 205 RECQL4
207 206 SPC24
208 207 TEDC2
209 208 AK4
210 209 AKR7A3
211 210 FLVCR1
212 211 KIF26B
213 212 LINC01116
214 213 TRIM46
215 214 TSACC
216 215 CRYBA2
217 216 AIM2
218 217 KIF15
219 218 MAD2L1
220 219 SFXN1
221 220 IL31RA
222 221 STEAP1
223 222 SP8
224 223 CTHRC1
225 224 MELK
226 225 TSHR
227 226 PGM2L1
228 227 SLC16A9
229 228 GJB2
230 229 SKA3
231 230 E2F7
232 231 TAF1D
233 232 GLB1L3
234 233 GPT2
235 234 PPP1R14D
236 235 NETO1
237 236 HTR3A
238 237 PLK1
239 238 GREM1
240 239 TTYH1
241 240 KLK6
242 241 RAB26
243 242 PBK
244 243 COL3A1
245 244 GDNF
246 245 SOX14
247 246 RAB3B
248 247 COL22A1
249 248 CKAP2L
250 249 BUB1
251 250 ONECUT1
252 251 CDK1
253 252 CST1
254 253 HOXB9
255 254 HS6ST2
256 255 P2RY6
257 256 RRM2
258 257 FRMD5
259 258 MTBP
260 259 C5orf34
261 260 FUT9
262 261 MYEOV
263 262 SYT12
264 263 C11orf86
265 264 MUC13
266 265 SPTBN2
267 266 NWD2
268 267 EXO1
269 268 ANKRD36C
270 269 IL20RB
271 270 LEP
272 271 UBE2C
273 272 MARCKSL1
274 273 ANKS4B
275 274 RMI2
276 275 ETV4
277 276 FAM172BP
278 277 GPX2
279 278 ATAD5
280 279 FUT2
281 280 CD19
282 281 DNAJC22
283 282 CPNE7
284 283 ANKRD18A
285 284 EMC3-AS1
286 285 NQO1
287 286 B4GALNT4
288 287 GALNT9
289 288 PYCR1
290 289 EPHA10
291 290 IQGAP3
292 291 KNTC1
293 292 POU3F2
294 293 CDCA2
295 294 PARPBP
296 295 PRAME
297 296 DNAH14
298 297 KIF18B
299 298 SAPCD2
300 299 THBS2
301 300 HPDL
302 301 ERCC6L
303 302 TNFRSF18
304 303 TMPRSS11A
305 304 BAGE2
306 305 HIST1H1C
307 306 ENTPD8
308 307 ATP2A1
309 308 XRCC2
310 309 HIST1H2AI
311 310 S100A2
312 311 HIST1H2AG
313 312 HIST1H2AD
314 313 SCN8A
315 314 HIST1H4C
316 315 DMBX1
317 316 PRB3
318 317 AKR1B10
319 318 EPS8L3
320 319 ARHGAP11A
321 320 SNORA73B
322 321 SNORA23
323 322 ZYG11A
324 323 LINC01270
325 324 IGFL2
326 325 FAM83A-AS1
327 326 LGR4
328 327 AKR7L
329 328 IGHG4
330 329 IGHG1
331 330 PPP1R14BP2
332 331 GPC2
333 332 LINC02418
334 333 VAC14-AS1
335 334 UBE2QL1
336 335 TNFRSF25
337 336 LINC01983
338 337 HAGLROS
339 338 PSMD10P2
340 339 AKR1B15
341 340 LINC02474
342 341 NKX1-2
343 342 ANKRD36BP2
344 343 FEZF1-AS1
345 344 FOXD3-AS1
346 345 DLX6-AS1
347 346 LINC00665
348 347 LINC01271
349 348 LINC02535
350 349 DSCAM-AS1
351 350 RPSAP52
352 351 SNHG3
353 352 CCDC169
354 353 MNX1-AS1
355 354 RPL18P13
356 355 LINC00461
357 356 LINC02014
358 357 LUCAT1
359 358 LINC02362
360 359 LINC01234
361 360 LINC00942
362 361 PVT1
363 362 SCARNA13
364 363 BBOX1-AS1
365 364 MEX3A
366 365 SNHG1
367 366 LINC00346
368 367 SALL3
369 368 POLG2
370 369 TUBB3
371 370 LINC02544
372 371 VPS9D1-AS1
373 372 LINC01977
374 373 RUNDC3A-AS1
375 374 AFAP1-AS1
376 375 LHX1
377 376 UHRF1
378 377 HIST1H2BF
379 378 NEFL
380 379 RDM1
381 380 HIST1H2AM
382 381 LINC01395
383 382 HELLPAR
384 383 SNHG4

66
intermediate-pathway-scripting/preworkshop_installations.R Normal file
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## Run this R script prior to the workshop. You can open it in RStudio and click "Source".
## These pacakges require R version 3.6.0 or later. Check by typing: R.version.string
##
## Open this script in RStudio and step through it line-by-line, reading the comments as you go.
##
## Please confirm the "Success" message prior to attending the workshop. If the script produced an "Error"
## message, even after repeated attempts, please contact the instructor.
############
## PART 1 ##
############
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
load.libs <- c(
"ggplot2",
"EnhancedVolcano",
"DOSE",
"GO.db",
"GSEABase",
"org.Hs.eg.db",
"clusterProfiler",
"dplyr",
"tidyr",
"ggplot2",
"stringr",
"RColorBrewer",
"rWikiPathways",
"RCy3")
options(install.packages.check.source = "no")
options(install.packages.compile.from.source = "never")
if (!require("pacman")) install.packages("pacman"); library(pacman)
p_load(load.libs, update = TRUE, character.only = TRUE)
status <- sapply(load.libs,require,character.only = TRUE)
if(all(status)){
print("SUCCESS: You have successfully installed and loaded all required libraries.")
} else{
cat("ERROR: One or more libraries failed to install correctly. Check the following list for FALSE cases and try again...\n\n")
status
}
## Troubleshooting Tips:
## * If you see errors related to 'data.table', 'units' or other missing packages, try these lines for each:
## remove.packages("data.table")
## install.packages("data.table")
## Then run the entire script again.
## * If you continue to see problems. You may try restarting R and RStudio. Then trying again.
## * If you still have issues, please email the instructor as soon as possible before the workshop.
############
## PART 2 ##
############
## We will also be connecting to Cytoscape from R. You will also need to install and launch Cytoscape:
#
# * Download the latest Cytoscape from http://www.cytoscape.org/download.php
# * Complete installation wizard
# * Launch Cytoscape
# Run this line to confirm a successful connection with Cytoscape
cytoscapePing()
# Then run these lines to install a few apps in Cytoscape
installApp('WikiPathways')
installApp('CyTargetLinker')
installApp('stringApp')